C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tripartite motif containing 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000132256 TRIM5 9606 - 11:5663557-5938619 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000380027 TRIM5-003 5663563-5872358 protein_coding
  ENST00000380034 TRIM5-001 5663557-5685063 protein_coding
  ENST00000396847 TRIM5-004 5663617-5685042 protein_coding
  ENST00000412903 TRIM5-012 5678320-5938619 protein_coding
  ENST00000419850 TRIM5-013 5679962-5685043 protein_coding
  ENST00000433961 TRIM5-005 5663564-5680232 nonsense_mediated_decay
  ENST00000438025 TRIM5-009 5663831-5679807 protein_coding
  ENST00000465634 TRIM5-010 5665880-5679833 processed_transcript
  ENST00000483835 TRIM5-008 5664058-5679857 processed_transcript
  ENST00000487241 TRIM5-007 5677946-5679931 retained_intron
  ENST00000492086 TRIM5-011 5665420-5679140 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000380034ENST00000396847ENST00000412903ENST00000433961ENST00000438025ENST00000465634ENST00000483835ENST00000487241ENST00000492086
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000380034 2.829±0.00 1.275±0.00 2.803±0.00 0.403±0.16 2.123±0.40 1.719±0.75 0.910±0.19 0.884±0.03 2.109±0.15 2.237±0.88 N/A 2.382±0.65 2.954±0.79 1.415±0.00
ENST00000396847 0.810±0.00 0.796±0.00 N/A N/A 0.603±0.00 N/A 0.533±0.00 1.323±0.09 0.766±0.00 1.437±0.01 0.978±0.00 1.127±0.42 N/A 0.993±0.02
ENST00000412903 N/A N/A N/A N/A N/A N/A N/A N/A 2.804±0.00 N/A 0.439±0.00 N/A N/A N/A
ENST00000433961 N/A 2.279±0.00 N/A 0.176±0.00 2.014±0.00 2.731±0.00 0.805±0.00 3.372±0.40 1.381±0.00 N/A N/A 2.330±0.00 1.627±0.37 1.336±0.00
ENST00000438025 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.661±0.00 3.995±0.00 1.361±0.00
ENST00000465634 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.042±0.00 N/A N/A
ENST00000483835 N/A N/A N/A N/A 3.500±0.00 N/A N/A 3.056±0.64 N/A N/A 0.083±0.00 N/A N/A 0.790±0.00
ENST00000487241 N/A N/A N/A N/A N/A 3.095±0.00 N/A N/A 2.249±0.00 2.931±0.00 N/A N/A N/A N/A
ENST00000492086 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.217±0.00 3.993±0.00 1.136±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000932 IDA cytoplasmic mRNA processing body
GO:0002218 IDA activation of innate immune response
GO:0002221 IDA pattern recognition receptor signaling pathway
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0008270 IEA zinc ion binding
GO:0008329 IDA signaling pattern recognition receptor activity
GO:0016032 IEA viral process
GO:0016874 IEA ligase activity
GO:0031664 IMP regulation of lipopolysaccharide-mediated signaling pathway
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 IMP positive regulation of MAPK cascade
GO:0045087 IDA innate immune response
GO:0046597 IDA negative regulation of viral entry into host cell
GO:0046872 IEA metal ion binding
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051607 TAS defense response to virus
GO:0070206 IDA protein trimerization
GO:0070534 IDA protein K63-linked ubiquitination
GO:1902187 IDA negative regulation of viral release from host cell

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000030921 Trim30a tripartite motif-containing 30A protein_coding Mus_musculus
ENSMUSG00000057143 Trim12c tripartite motif-containing 12C protein_coding Mus_musculus
ENSMUSG00000057596 Trim30d tripartite motif-containing 30D protein_coding Mus_musculus
ENSMUSG00000060441 Trim5 tripartite motif-containing 5 protein_coding Mus_musculus
ENSMUSG00000066258 Trim12a tripartite motif-containing 12A protein_coding Mus_musculus
ENSMUSG00000078616 Trim30c tripartite motif-containing 30C protein_coding Mus_musculus

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