C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 12
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000139625 MAP3K12 9606 - 12:53479669-53500063 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000267079 MAP3K12-004 53479669-53499615 protein_coding
  ENST00000547020 MAP3K12-006 53480490-53486728 retained_intron
  ENST00000547035 MAP3K12-005 53481122-53493866 protein_coding
  ENST00000547151 MAP3K12-011 53486443-53499457 processed_transcript
  ENST00000547488 MAP3K12-002 53481121-53499456 protein_coding
  ENST00000547803 MAP3K12-012 53486985-53493070 retained_intron
  ENST00000548565 MAP3K12-007 53487315-53500063 protein_coding
  ENST00000548690 MAP3K12-008 53485036-53485707 retained_intron
  ENST00000551511 MAP3K12-009 53481122-53482587 retained_intron
  ENST00000551895 MAP3K12-010 53486847-53499458 retained_intron
  ENST00000552365 MAP3K12-001 53481182-53487909 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastKidneyLungOvaryENST00000267079ENST00000547488
Transcript ID Adrenal Brain Breast Kidney Lung Ovary
ENST00000267079 23.360±0.00 13.539±9.31 18.371±0.00 23.716±19.95 37.246±0.00 19.498±14.07
ENST00000547488 N/A 7.237±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009B4 CIL_0009B4_0001 VISTA 12:53396852-53997557
CIL_00033G CIL_00033G_0002 CGP 12:53452102-53500063

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 IEA activation of MAPKK activity
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 TAS cytoplasm
GO:0005829 ISS cytosol
GO:0005886 ISS plasma membrane
GO:0006468 ISS:IEA protein phosphorylation
GO:0007254 ISS JNK cascade
GO:0016020 ISS membrane
GO:0016572 ISS histone phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 ISS peptidyl-serine phosphorylation
GO:0018107 ISS peptidyl-threonine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0030424 IEA axon
GO:0030426 IEA growth cone
GO:0035556 TAS intracellular signal transduction
GO:0042803 ISS protein homodimerization activity
GO:0046777 ISS:IEA protein autophosphorylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042565 MAP3K12 mitogen-activated protein kinase kinase kinase 12 (map3k12), mRNA protein_coding Danio_rerio
ENSMUSG00000023050 Map3k12 mitogen-activated protein kinase kinase kinase 12 protein_coding Mus_musculus

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