C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phospholipase A2, group IB (pancreas)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000170890 PLA2G1B 9606 - 12:120322111-120327789 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308366 PLA2G1B-001 120322111-120327789 protein_coding
  ENST00000423423 PLA2G1B-002 120322115-120327779 protein_coding
  ENST00000549767 PLA2G1B-003 120322117-120326093 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonHeartKidneyLiverLungOvaryTestisENST00000308366ENST00000423423ENST00000549767
Transcript ID Adrenal Brain Breast Colon Heart Kidney Liver Lung Ovary Testis
ENST00000308366 N/A N/A 1.191±0.00 N/A N/A N/A N/A 3.573±0.26 1.740±1.74 1.271±0.00
ENST00000423423 N/A N/A N/A N/A N/A 0.050±0.00 0.209±0.00 N/A 1.384±0.00 N/A
ENST00000549767 0.141±0.00 0.077±0.00 0.258±0.00 0.103±0.00 0.189±0.00 N/A N/A 3.147±0.00 1.495±1.08 1.209±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009CQ CIL_0009CQ_0001 VISTA 12:119991644-120595694
CIL_0007ZA CIL_0007ZA_0001 VISTA 12:120240385-120840841

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 ISS activation of MAPK activity
GO:0002227 IDA innate immune response in mucosa
GO:0002446 ISS neutrophil mediated immunity
GO:0004623 IDA phospholipase A2 activity
GO:0005102 IDA receptor binding
GO:0005509 IEA:IDA calcium ion binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0006633 IDA fatty acid biosynthetic process
GO:0006644 TAS phospholipid metabolic process
GO:0006654 TAS phosphatidic acid biosynthetic process
GO:0007015 TAS actin filament organization
GO:0007165 TAS signal transduction
GO:0009986 IDA cell surface
GO:0010524 ISS positive regulation of calcium ion transport into cytosol
GO:0015758 ISS glucose transport
GO:0016042 IEA lipid catabolic process
GO:0019370 ISS leukotriene biosynthetic process
GO:0019731 IDA antibacterial humoral response
GO:0030141 IEA secretory granule
GO:0030593 ISS neutrophil chemotaxis
GO:0032052 ISS bile acid binding
GO:0032431 TAS activation of phospholipase A2 activity
GO:0032637 ISS interleukin-8 production
GO:0032869 ISS cellular response to insulin stimulus
GO:0035556 ISS intracellular signal transduction
GO:0036148 TAS phosphatidylglycerol acyl-chain remodeling
GO:0036149 TAS phosphatidylinositol acyl-chain remodeling
GO:0036150 TAS phosphatidylserine acyl-chain remodeling
GO:0036151 TAS phosphatidylcholine acyl-chain remodeling
GO:0036152 TAS phosphatidylethanolamine acyl-chain remodeling
GO:0044240 IDA multicellular organismal lipid catabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045740 IDA positive regulation of DNA replication
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046470 IDA phosphatidylcholine metabolic process
GO:0046474 TAS glycerophospholipid biosynthetic process
GO:0047498 IDA calcium-dependent phospholipase A2 activity
GO:0048146 IC positive regulation of fibroblast proliferation
GO:0050482 TAS arachidonic acid secretion
GO:0050714 TAS positive regulation of protein secretion
GO:0050778 ISS positive regulation of immune response
GO:0050830 IDA defense response to Gram-positive bacterium
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009153 pla2g1b phospholipase A2, group IB (pancreas) protein_coding Danio_rerio
ENSMUSG00000029522 Pla2g1b phospholipase A2, group IB, pancreas protein_coding Mus_musculus

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