C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rap guanine nucleotide exchange factor (GEF) 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000118340 Rapgef2-002 ENSMUSG00000062232 10090 - 3:79062528-79145875 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000118340
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000118340 4.099±1.32 4.945±2.03 7.148±6.83 3.671±1.96 2.171±1.53 1.751±0.72 1.380±0.72 1.098±0.60 4.642±0.96 0.715±0.39 5.640±2.44 5.315±3.08 0.855±0.10

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005088 IEA Ras guanyl-nucleotide exchange factor activity
GO:0005737 IEA cytoplasm
GO:0005770 IEA late endosome
GO:0005886 IEA plasma membrane
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007218 IEA neuropeptide signaling pathway
GO:0008285 IEA negative regulation of cell proliferation
GO:0010976 IEA positive regulation of neuron projection development
GO:0016020 IEA membrane
GO:0017034 IEA Rap guanyl-nucleotide exchange factor activity
GO:0019901 IEA protein kinase binding
GO:0030165 IEA PDZ domain binding
GO:0030552 IEA cAMP binding
GO:0031175 IEA neuron projection development
GO:0031547 IEA brain-derived neurotrophic factor receptor signaling pathway
GO:0031697 IEA beta-1 adrenergic receptor binding
GO:0032320 IEA positive regulation of Ras GTPase activity
GO:0032486 IEA Rap protein signal transduction
GO:0032854 IEA positive regulation of Rap GTPase activity
GO:0038180 IEA nerve growth factor signaling pathway
GO:0043005 IEA neuron projection
GO:0043025 IEA neuronal cell body
GO:0043234 IEA protein complex
GO:0043950 IEA positive regulation of cAMP-mediated signaling
GO:0045202 IEA synapse
GO:0045860 IEA positive regulation of protein kinase activity
GO:0046582 IEA Rap GTPase activator activity
GO:0048167 IEA regulation of synaptic plasticity
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050699 IEA WW domain binding
GO:0050774 IEA negative regulation of dendrite morphogenesis
GO:0061028 IEA establishment of endothelial barrier
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071320 IEA cellular response to cAMP
GO:0071321 IEA cellular response to cGMP
GO:0071880 IEA adenylate cyclase-activating adrenergic receptor signaling pathway
GO:1901888 IEA regulation of cell junction assembly
GO:1990090 IEA cellular response to nerve growth factor stimulus
GO:2000481 IEA positive regulation of cAMP-dependent protein kinase activity
GO:2000670 IEA positive regulation of dendritic cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000264431 RAPGEF2-001 protein_coding Homo_sapiens 0 5782
ENST00000510253 RAPGEF2-010 protein_coding Homo_sapiens 0 472
ENST00000510510 RAPGEF2-008 protein_coding Homo_sapiens 0 616
ENST00000513816 RAPGEF2-002 retained_intron Homo_sapiens 0 444

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