C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000366667 AGT-001 ENSG00000135744 9606 - 1:230702523-230714297 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000366667
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000366667 10.217±0.00 22.658±0.00 1.363±0.00 90.401±84.38 4.796±1.52 3.664±2.99 20.553±18.32 89.483±40.39 1103.417±1102.88 6.104±0.00 11.779±7.06 2.017±1.02 1.494±0.80 3.855±0.88

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007WK CIL_0007WK_0001 VISTA 1:230548777-231152235
CIL_000610 CIL_000610_0001 CGP 1:230642489-230714297
CIL_000615 CIL_000615_0001 CGP 1:230702523-230802003

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001543 IEA ovarian follicle rupture
GO:0001558 NAS regulation of cell growth
GO:0001568 IEA blood vessel development
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001819 TAS positive regulation of cytokine production
GO:0001822 IMP kidney development
GO:0001974 TAS blood vessel remodeling
GO:0001991 IEA regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0001998 IEA angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001999 IEA renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
GO:0002003 TAS angiotensin maturation
GO:0002016 NAS regulation of blood volume by renin-angiotensin
GO:0002018 NAS renin-angiotensin regulation of aldosterone production
GO:0002019 NAS regulation of renal output by angiotensin
GO:0002034 TAS regulation of blood vessel size by renin-angiotensin
GO:0002035 IEA brain renin-angiotensin system
GO:0003014 IDA renal system process
GO:0003051 IEA angiotensin-mediated drinking behavior
GO:0003331 IEA positive regulation of extracellular matrix constituent secretion
GO:0004867 IBA serine-type endopeptidase inhibitor activity
GO:0005179 ISS hormone activity
GO:0005515 IPI protein binding
GO:0005576 NAS extracellular region
GO:0005615 ISS extracellular space
GO:0005737 IEA cytoplasm
GO:0006883 IEA cellular sodium ion homeostasis
GO:0007160 IEA cell-matrix adhesion
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007199 TAS G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007200 NAS phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 IEA activation of phospholipase C activity
GO:0007250 IEA activation of NF-kappaB-inducing kinase activity
GO:0007263 TAS nitric oxide mediated signal transduction
GO:0007267 TAS cell-cell signaling
GO:0007565 IEA female pregnancy
GO:0007568 IEA aging
GO:0007588 IEA excretion
GO:0008065 IEA establishment of blood-nerve barrier
GO:0008083 TAS growth factor activity
GO:0008217 IEA regulation of blood pressure
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0009409 IEA response to cold
GO:0009651 IEA response to salt stress
GO:0010468 IEA regulation of gene expression
GO:0010535 IMP positive regulation of activation of JAK2 kinase activity
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0010613 ISS positive regulation of cardiac muscle hypertrophy
GO:0010628 IEA positive regulation of gene expression
GO:0010744 IC positive regulation of macrophage derived foam cell differentiation
GO:0010873 IDA positive regulation of cholesterol esterification
GO:0010951 IBA negative regulation of endopeptidase activity
GO:0014061 IEA regulation of norepinephrine secretion
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014824 IEA artery smooth muscle contraction
GO:0014873 ISS response to muscle activity involved in regulation of muscle adaptation
GO:0016176 TAS superoxide-generating NADPH oxidase activator activity
GO:0016525 IEA negative regulation of angiogenesis
GO:0019229 NAS regulation of vasoconstriction
GO:0030162 IBA regulation of proteolysis
GO:0030198 IEA extracellular matrix organization
GO:0030308 IEA negative regulation of cell growth
GO:0030432 IEA peristalsis
GO:0031701 IEA angiotensin receptor binding
GO:0031702 IPI type 1 angiotensin receptor binding
GO:0031703 IPI type 2 angiotensin receptor binding
GO:0032270 IDA positive regulation of cellular protein metabolic process
GO:0032930 IEA positive regulation of superoxide anion generation
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0033864 TAS positive regulation of NAD(P)H oxidase activity
GO:0034104 IEA negative regulation of tissue remodeling
GO:0034374 NAS low-density lipoprotein particle remodeling
GO:0035411 IEA catenin import into nucleus
GO:0035813 NAS regulation of renal sodium excretion
GO:0035815 IEA positive regulation of renal sodium excretion
GO:0040018 IEA positive regulation of multicellular organism growth
GO:0042127 NAS regulation of cell proliferation
GO:0042310 IEA vasoconstriction
GO:0042311 IEA vasodilation
GO:0042445 IEA hormone metabolic process
GO:0042756 IEA drinking behavior
GO:0042981 IEA regulation of apoptotic process
GO:0043085 IEA positive regulation of catalytic activity
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0044255 TAS cellular lipid metabolic process
GO:0044267 TAS cellular protein metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045723 IEA positive regulation of fatty acid biosynthetic process
GO:0045742 IDA positive regulation of epidermal growth factor receptor signaling pathway
GO:0045777 IEA positive regulation of blood pressure
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045909 IEA positive regulation of vasodilation
GO:0046622 IEA positive regulation of organ growth
GO:0048143 IEA astrocyte activation
GO:0048144 IEA fibroblast proliferation
GO:0048146 ISS positive regulation of fibroblast proliferation
GO:0048169 IEA regulation of long-term neuronal synaptic plasticity
GO:0048659 IEA smooth muscle cell proliferation
GO:0050663 IEA cytokine secretion
GO:0050727 IEA regulation of inflammatory response
GO:0050729 TAS positive regulation of inflammatory response
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0051092 TAS positive regulation of NF-kappaB transcription factor activity
GO:0051145 IEA smooth muscle cell differentiation
GO:0051387 IDA negative regulation of neurotrophin TRK receptor signaling pathway
GO:0051403 IEA stress-activated MAPK cascade
GO:0051924 IEA regulation of calcium ion transport
GO:0051969 IEA regulation of transmission of nerve impulse
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0061098 IMP positive regulation of protein tyrosine kinase activity
GO:0070062 IDA extracellular vesicular exosome
GO:0070371 IEA ERK1 and ERK2 cascade
GO:0070471 IEA uterine smooth muscle contraction
GO:0071260 IEA cellular response to mechanical stimulus
GO:0072562 IDA blood microparticle
GO:0090190 IDA positive regulation of branching involved in ureteric bud morphogenesis
GO:1900020 IEA positive regulation of protein kinase C activity
GO:2000379 TAS positive regulation of reactive oxygen species metabolic process
GO:2000650 TAS negative regulation of sodium ion transmembrane transporter activity
GO:2001238 IDA positive regulation of extrinsic apoptotic signaling pathway

Homologs

No Homologs available.

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