C-It-Loci is a tool to explore and to compare the expression profiles of conserved loci among various tissues in three organisms. Conversed loci are pairs of adjacent homologous protein-coding genes shared between one or more species. Expression profiles are based on RNA-seq data from many sources to derive tissue enrichment or specificity. Classifications of transcripts are based on the latest release of ENSEMBL, which will be updated in a timely manner. In addition to protein-coding genes, expression profiles of yet-to-be-characterized long non-coding RNAs (lncRNAs) are included. To define species-conservation of lncRNAs, we introduced the concept called "positional conservation" on top of "sequence conservation", which is the most common way to find homologous lncRNAs among species. We anticipate that C-It-Loci will be a valuable tool to perform in silico screening of tissue-enriched lncRNAs to be studied further by biological experiments.

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