C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: presenilin 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000015540 psen2 7955 - 1:51558297-51571727 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000006381 psen2-001 51558297-51571727 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000006381
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000006381 3.477±2.12 4.848±1.20 3.510±1.15 0.897±0.00 5.807±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000139 IEA Golgi membrane
GO:0004175 IBA endopeptidase activity
GO:0004190 IEA aspartic-type endopeptidase activity
GO:0005634 IBA nucleus
GO:0005743 IBA mitochondrial inner membrane
GO:0005765 IBA lysosomal membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005789 IEA endoplasmic reticulum membrane
GO:0005794 IEA Golgi apparatus
GO:0005887 IBA integral to plasma membrane
GO:0005938 IBA cell cortex
GO:0006508 IEA proteolysis
GO:0006509 IBA membrane protein ectodomain proteolysis
GO:0006816 IBA calcium ion transport
GO:0007219 IMP Notch signaling pathway
GO:0007220 IBA Notch receptor processing
GO:0007420 IMP brain development
GO:0008233 IEA peptidase activity
GO:0009986 IBA cell surface
GO:0016020 IEA membrane
GO:0016021 IEA integral to membrane
GO:0016324 IBA apical plasma membrane
GO:0016787 IEA hydrolase activity
GO:0022008 IMP neurogenesis
GO:0030018 IBA Z disc
GO:0030318 IMP melanocyte differentiation
GO:0030424 IBA axon
GO:0030426 IBA growth cone
GO:0031594 IBA neuromuscular junction
GO:0035253 IBA ciliary rootlet
GO:0042987 IBA amyloid precursor protein catabolic process
GO:0043025 IBA neuronal cell body
GO:0043198 IBA dendritic shaft
GO:0045121 IBA membrane raft
GO:0048471 IBA perinuclear region of cytoplasm
GO:0050435 IBA beta-amyloid metabolic process
GO:0061053 IMP somite development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000143801 PSEN2 presenilin 2 protein_coding Homo_sapiens
ENSMUSG00000010609 Psen2 presenilin 2 protein_coding Mus_musculus

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