C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lysine (K)-specific methyltransferase 2E
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000005483 KMT2E 9606 + 7:105014179-105114361 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000257745 KMT2E-201 105014190-105114084 protein_coding
  ENST00000311117 KMT2E-001 105014179-105114085 protein_coding
  ENST00000334877 KMT2E-202 105014190-105114361 protein_coding
  ENST00000334884 KMT2E-004 105014190-105114361 nonsense_mediated_decay
  ENST00000334914 KMT2E-203 105040953-105113333 protein_coding
  ENST00000468607 KMT2E-014 105062198-105063827 retained_intron
  ENST00000473063 KMT2E-007 105109040-105110867 protein_coding
  ENST00000474203 KMT2E-012 105014461-105063377 protein_coding
  ENST00000476671 KMT2E-003 105014218-105091609 protein_coding
  ENST00000478079 KMT2E-018 105107900-105110556 nonsense_mediated_decay
  ENST00000478990 KMT2E-009 105014206-105090132 protein_coding
  ENST00000479838 KMT2E-016 105101471-105102649 protein_coding
  ENST00000480368 KMT2E-011 105014207-105040856 processed_transcript
  ENST00000482560 KMT2E-010 105038126-105090132 nonsense_mediated_decay
  ENST00000485619 KMT2E-013 105061918-105063386 retained_intron
  ENST00000495267 KMT2E-008 105014208-105074777 protein_coding
  ENST00000496191 KMT2E-015 105077116-105077808 retained_intron
  ENST00000622386 KMT2E-204 105063350-105101478 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000257745ENST00000311117ENST00000334877ENST00000334884ENST00000334914ENST00000622386
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000257745 9.591±0.00 6.105±0.00 N/A N/A 5.062±0.00 7.397±0.00 2.144±0.00 5.617±0.00 1.456±0.00 N/A 4.897±0.00 8.721±3.93 3.342±2.25 9.361±0.00
ENST00000311117 N/A N/A 4.555±0.00 N/A 6.803±0.00 4.280±0.00 N/A 1.779±0.00 6.102±0.00 N/A 1.356±0.00 N/A 1.296±0.00 N/A
ENST00000334877 3.460±0.00 2.790±0.00 N/A 4.706±0.00 3.774±0.08 3.274±0.29 2.041±0.55 1.683±0.48 6.123±0.00 6.090±0.00 N/A 6.994±0.65 N/A N/A
ENST00000334884 N/A N/A N/A N/A N/A N/A N/A N/A 0.606±0.00 N/A N/A 8.346±0.00 N/A N/A
ENST00000334914 N/A N/A 3.585±0.00 N/A N/A N/A 1.746±0.53 N/A N/A 6.108±0.00 3.381±0.00 3.920±0.00 1.087±0.00 N/A
ENST00000622386 N/A N/A N/A N/A 10.520±0.00 N/A N/A N/A N/A N/A N/A 26.837±0.00 14.664±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005BG CIL_0005BG_0002 CGP 7:104328656-105114361
CIL_00040Y CIL_00040Y_0001 CGP 7:105014179-105399308

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002446 ISS neutrophil mediated immunity
GO:0003713 IMP transcription coactivator activity
GO:0005515 IPI:IEA protein binding
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006306 ISS DNA methylation
GO:0006351 IEA transcription, DNA-templated
GO:0007050 IEA cell cycle arrest
GO:0008270 IEA zinc ion binding
GO:0019899 IPI enzyme binding
GO:0030218 ISS erythrocyte differentiation
GO:0030854 IMP positive regulation of granulocyte differentiation
GO:0042119 ISS neutrophil activation
GO:0042800 IDA histone methyltransferase activity (H3-K4 specific)
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0048384 IMP retinoic acid receptor signaling pathway
GO:0051568 IDA histone H3-K4 methylation
GO:0070688 IDA MLL5-L complex
GO:0071300 IDA cellular response to retinoic acid

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007523 kmt2e lysine (K)-specific methyltransferase 2E protein_coding Danio_rerio
ENSMUSG00000029004 Kmt2e lysine (K)-specific methyltransferase 2E protein_coding Mus_musculus

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