C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NADPH oxidase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000007952 NOX1 9606 - X:100843324-100874345 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000217885 NOX1-003 100843836-100874209 protein_coding
  ENST00000372960 NOX1-201 100843324-100874345 protein_coding
  ENST00000372964 NOX1-002 100843333-100874209 protein_coding
  ENST00000372966 NOX1-001 100843324-100874345 protein_coding
  ENST00000427768 NOX1-004 100843783-100850336 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonLiverLungOvaryPlacentaTestisENST00000217885ENST00000372960ENST00000372964ENST00000372966ENST00000427768
Transcript ID Adipose Brain Breast Colon Liver Lung Ovary Placenta Testis
ENST00000217885 N/A N/A N/A N/A N/A N/A 0.754±0.00 0.031±0.00 N/A
ENST00000372960 0.015±0.00 0.028±0.00 0.604±0.00 1.962±0.00 N/A N/A 0.991±0.00 N/A 0.009±0.00
ENST00000372964 N/A N/A N/A N/A N/A 0.210±0.00 N/A 0.075±0.00 N/A
ENST00000372966 N/A N/A N/A 3.245±2.53 N/A N/A 2.610±1.31 N/A 0.009±0.00
ENST00000427768 N/A N/A N/A N/A 0.416±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000YO CIL_0000YO_0002 CGP X:100820359-100874345
CIL_0007B9 CIL_0007B9_0001 CGP X:100843324-100929433

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IMP angiogenesis
GO:0003081 IEA regulation of systemic arterial blood pressure by renin-angiotensin
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005768 IEA endosome
GO:0005769 IDA early endosome
GO:0006739 IC NADP metabolic process
GO:0006801 IMP superoxide metabolic process
GO:0006954 TAS inflammatory response
GO:0007165 TAS signal transduction
GO:0008217 TAS regulation of blood pressure
GO:0008284 IDA positive regulation of cell proliferation
GO:0010575 IEP positive regulation vascular endothelial growth factor production
GO:0015992 IDA proton transport
GO:0016020 IEA membrane
GO:0016021 IC integral component of membrane
GO:0016175 IC superoxide-generating NADPH oxidase activity
GO:0016477 IMP cell migration
GO:0016491 IEA oxidoreductase activity
GO:0030054 IEA cell junction
GO:0030171 IDA voltage-gated proton channel activity
GO:0030198 IEA extracellular matrix organization
GO:0034765 IEA regulation of ion transmembrane transport
GO:0042554 IDA superoxide anion generation
GO:0042743 IDA hydrogen peroxide metabolic process
GO:0043020 IDA NADPH oxidase complex
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045726 IMP positive regulation of integrin biosynthetic process
GO:0045730 TAS respiratory burst
GO:0046330 IEA positive regulation of JNK cascade
GO:0046872 IEA metal ion binding
GO:0048365 IPI Rac GTPase binding
GO:0048661 ISS positive regulation of smooth muscle cell proliferation
GO:0050661 IC NADP binding
GO:0051454 IDA intracellular pH elevation
GO:0055114 IDA:IEA oxidation-reduction process
GO:0071438 IDA invadopodium membrane
GO:0071455 IEA cellular response to hyperoxia
GO:0072592 IEA oxygen metabolic process
GO:1902177 IEA positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1990451 IDA cellular stress response to acidic pH

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070062 nox1 NADPH oxidase 1 protein_coding Danio_rerio
ENSDARG00000087574 nox1 NADPH oxidase 1 protein_coding Danio_rerio
ENSMUSG00000031257 Nox1 NADPH oxidase 1 protein_coding Mus_musculus

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