C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: polymerase (DNA directed), alpha 2, accessory subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000014138 POLA2 9606 + 11:65261762-65305589 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265465 POLA2-001 65261762-65298685 protein_coding
  ENST00000525924 POLA2-008 65282507-65305589 protein_coding
  ENST00000527618 POLA2-004 65280468-65297616 retained_intron
  ENST00000527850 POLA2-003 65261920-65296498 nonsense_mediated_decay
  ENST00000532391 POLA2-005 65266481-65278826 protein_coding
  ENST00000532469 POLA2-002 65261932-65280020 retained_intron
  ENST00000533192 POLA2-006 65287602-65294776 retained_intron
  ENST00000534785 POLA2-007 65294178-65297552 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265465ENST00000525924ENST00000527618ENST00000527850ENST00000532469ENST00000534785
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265465 0.611±0.00 1.976±0.00 0.272±0.00 1.406±0.00 1.144±0.00 0.903±0.31 0.383±0.28 1.081±0.80 0.300±0.03 1.360±0.00 0.139±0.00 2.612±0.38 1.858±0.79 2.462±0.53
ENST00000525924 N/A N/A N/A N/A 1.603±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000527618 N/A N/A N/A N/A N/A 0.608±0.00 N/A 0.916±0.00 N/A 0.383±0.00 0.711±0.00 N/A N/A N/A
ENST00000527850 N/A N/A 0.492±0.00 0.789±0.00 N/A N/A N/A N/A N/A 0.952±0.00 N/A N/A 1.398±0.00 N/A
ENST00000532469 N/A N/A N/A N/A 1.429±0.00 2.164±0.00 N/A 0.546±0.00 0.415±0.00 0.514±0.00 0.363±0.00 1.445±0.00 N/A N/A
ENST00000534785 2.369±0.00 3.495±0.00 N/A N/A 2.609±0.00 3.936±0.00 1.997±0.00 6.664±0.00 1.281±0.00 3.927±0.00 1.592±0.59 N/A 3.539±0.48 7.610±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008W1 CIL_0008W1_0001 VISTA 11:65187233-65790923

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IEA protein import into nucleus, translocation
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0000722 TAS telomere maintenance via recombination
GO:0000723 TAS telomere maintenance
GO:0003674 ND molecular_function
GO:0003677 IEA DNA binding
GO:0003887 IEA DNA-directed DNA polymerase activity
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005658 IBA alpha DNA polymerase:primase complex
GO:0005737 IDA cytoplasm
GO:0006260 NAS:IEA DNA replication
GO:0006270 IBA DNA replication initiation
GO:0006271 TAS DNA strand elongation involved in DNA replication
GO:0032201 TAS telomere maintenance via semi-conservative replication
GO:0046982 IBA protein heterodimerization activity
GO:0071897 IEA DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015070 pola2 polymerase (DNA directed), alpha 2 protein_coding Danio_rerio
ENSMUSG00000024833 Pola2 polymerase (DNA directed), alpha 2 protein_coding Mus_musculus

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