C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ISL LIM homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000016082 ISL1 9606 + 5:51383391-51394738 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000230658 ISL1-001 51383391-51394738 protein_coding
  ENST00000505475 ISL1-006 51386204-51393567 processed_transcript
  ENST00000511384 ISL1-003 51383672-51393610 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonLungOvaryPlacentaTestisENST00000230658ENST00000505475ENST00000511384
Transcript ID Adipose Adrenal Brain Breast Colon Lung Ovary Placenta Testis
ENST00000230658 0.013±0.00 N/A 0.022±0.00 N/A 0.203±0.00 N/A 0.017±0.00 3.356±0.97 1.369±0.16
ENST00000505475 0.024±0.00 0.015±0.00 N/A 0.031±0.00 0.712±0.00 0.104±0.00 N/A N/A N/A
ENST00000511384 N/A N/A N/A N/A 0.135±0.00 N/A 0.034±0.00 3.099±0.00 0.996±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009BI CIL_0009BI_0001 VISTA 5:50795065-51396423
CIL_000931 CIL_000931_0001 VISTA 5:50872116-51474155
CIL_0008U0 CIL_0008U0_0001 VISTA 5:50885638-51486644
CIL_0007JG CIL_0007JG_0001 UCNEbase 5:51039710-52466387
CIL_000918 CIL_000918_0001 VISTA 5:51111733-51713370
CIL_0008KS CIL_0008KS_0001 VISTA 5:51258610-51860379
CIL_00083D CIL_00083D_0001 VISTA 5:51364298-51965733

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001105 IDA RNA polymerase II transcription coactivator activity
GO:0001158 IDA enhancer sequence-specific DNA binding
GO:0001755 IEA neural crest cell migration
GO:0003007 IEA heart morphogenesis
GO:0003139 IMP secondary heart field specification
GO:0003148 ISS outflow tract septum morphogenesis
GO:0003151 ISS outflow tract morphogenesis
GO:0003203 ISS endocardial cushion morphogenesis
GO:0003215 ISS cardiac right ventricle morphogenesis
GO:0003266 IEA regulation of secondary heart field cardioblast proliferation
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0005515 IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 NAS nucleus
GO:0005737 NAS cytoplasm
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007507 IEA heart development
GO:0008270 IEA zinc ion binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0010468 IEA regulation of gene expression
GO:0010575 ISS positive regulation vascular endothelial growth factor production
GO:0016922 ISS ligand-dependent nuclear receptor binding
GO:0021520 IEA spinal cord motor neuron cell fate specification
GO:0021522 ISS spinal cord motor neuron differentiation
GO:0021524 IEA visceral motor neuron differentiation
GO:0021559 ISS trigeminal nerve development
GO:0021983 IEA pituitary gland development
GO:0030182 IEA neuron differentiation
GO:0030331 ISS estrogen receptor binding
GO:0031016 ISS pancreas development
GO:0031103 IEA axon regeneration
GO:0031290 IEA retinal ganglion cell axon guidance
GO:0032024 IC positive regulation of insulin secretion
GO:0032725 ISS positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 ISS positive regulation of interferon-gamma production
GO:0032730 ISS positive regulation of interleukin-1 alpha production
GO:0032731 ISS positive regulation of interleukin-1 beta production
GO:0032735 ISS positive regulation of interleukin-12 production
GO:0032755 ISS positive regulation of interleukin-6 production
GO:0032760 ISS positive regulation of tumor necrosis factor production
GO:0033147 ISS negative regulation of intracellular estrogen receptor signaling pathway
GO:0042517 IEA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043388 IEA positive regulation of DNA binding
GO:0043425 IPI bHLH transcription factor binding
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045766 ISS positive regulation of angiogenesis
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048663 IEA neuron fate commitment
GO:0048665 ISS neuron fate specification
GO:0048762 ISS mesenchymal cell differentiation
GO:0048880 ISS sensory system development
GO:0048935 IEA peripheral nervous system neuron development
GO:0048936 ISS peripheral nervous system neuron axonogenesis
GO:0050728 ISS negative regulation of inflammatory response
GO:0055010 ISS ventricular cardiac muscle tissue morphogenesis
GO:0060037 ISS pharyngeal system development
GO:0060379 IEA cardiac muscle cell myoblast differentiation
GO:0060384 ISS innervation
GO:0060413 ISS atrial septum morphogenesis
GO:0060913 IDA cardiac cell fate determination
GO:0071385 ISS cellular response to glucocorticoid stimulus
GO:0071657 ISS positive regulation of granulocyte colony-stimulating factor production
GO:0090074 ISS negative regulation of protein homodimerization activity
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:1901258 ISS positive regulation of macrophage colony-stimulating factor production

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004023 isl1 islet1 protein_coding Danio_rerio
ENSMUSG00000042258 Isl1 ISL1 transcription factor, LIM/homeodomain protein_coding Mus_musculus

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