C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: vinculin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000035403 VCL 9606 + 10:73995193-74121363 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000211998 VCL-201 73998114-74120152 protein_coding
  ENST00000372755 VCL-001 73998114-74121363 protein_coding
  ENST00000436396 VCL-002 74083476-74120160 protein_coding
  ENST00000461383 VCL-005 74043091-74063890 processed_transcript
  ENST00000472585 VCL-004 74104928-74108975 retained_intron
  ENST00000478896 VCL-003 73998116-74105293 processed_transcript
  ENST00000623461 VCL-007 73995193-74120160 processed_transcript
  ENST00000624354 VCL-006 73998114-74118048 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000211998ENST00000372755ENST00000436396ENST00000623461ENST00000624354
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000211998 11.847±0.00 25.631±0.00 5.637±0.00 2.471±0.49 16.574±2.72 27.452±7.77 24.882±17.84 11.499±10.52 21.509±18.82 23.938±15.54 16.738±4.53 9.396±5.20 10.674±1.86 18.906±10.21
ENST00000372755 N/A N/A N/A N/A N/A N/A N/A 1.349±0.00 N/A N/A N/A N/A N/A N/A
ENST00000436396 11.619±0.00 19.322±0.00 N/A 2.619±0.00 10.983±0.00 26.804±0.00 19.428±0.00 14.425±0.00 3.914±0.00 24.698±0.00 6.468±0.00 8.125±0.02 N/A 13.618±0.00
ENST00000623461 N/A N/A 2.331±0.00 0.601±0.00 3.652±0.00 N/A 2.157±0.00 N/A N/A 3.462±0.00 N/A 2.545±0.00 N/A N/A
ENST00000624354 N/A N/A 3.948±0.00 N/A 11.050±0.00 7.930±0.00 N/A 1.288±0.00 N/A N/A N/A 8.711±2.01 24.507±0.00 4.453±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00008T CIL_00008T_0001 CGP 10:73995193-74151063

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002009 IMP morphogenesis of an epithelium
GO:0002162 IPI dystroglycan binding
GO:0002576 TAS platelet degranulation
GO:0003779 IDA actin binding
GO:0005198 IEA structural molecule activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 TAS cytoskeleton
GO:0005886 IEA plasma membrane
GO:0005911 ISS cell-cell junction
GO:0005912 ISS adherens junction
GO:0005913 IDA cell-cell adherens junction
GO:0005916 IEA fascia adherens
GO:0005925 ISS focal adhesion
GO:0006928 TAS cellular component movement
GO:0006936 TAS muscle contraction
GO:0007155 TAS:IEA cell adhesion
GO:0007160 TAS cell-matrix adhesion
GO:0007596 TAS blood coagulation
GO:0008013 ISS beta-catenin binding
GO:0015629 IEA actin cytoskeleton
GO:0030032 ISS lamellipodium assembly
GO:0030055 NAS cell-substrate junction
GO:0030168 TAS platelet activation
GO:0030334 IEA regulation of cell migration
GO:0030336 TAS negative regulation of cell migration
GO:0031982 IDA vesicle
GO:0034333 IMP adherens junction assembly
GO:0034394 IMP protein localization to cell surface
GO:0043034 ISS costamere
GO:0043234 IDA protein complex
GO:0043297 IMP apical junction assembly
GO:0045294 IPI alpha-catenin binding
GO:0045296 ISS cadherin binding
GO:0048675 IEA axon extension
GO:0051015 IEA actin filament binding
GO:0070062 IDA extracellular vesicular exosome
GO:0070527 IMP platelet aggregation
GO:0090136 IMP epithelial cell-cell adhesion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044968 vcla vinculin a protein_coding Danio_rerio
ENSMUSG00000021823 Vcl vinculin protein_coding Mus_musculus

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