C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: TIMP metallopeptidase inhibitor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000035862 TIMP2 9606 - 17:78852977-78925387 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262768 TIMP2-001 78852977-78925387 protein_coding
  ENST00000536189 TIMP2-003 78852977-78922401 protein_coding
  ENST00000585421 TIMP2-008 78852977-78874150 protein_coding
  ENST00000586057 TIMP2-004 78852981-78874089 protein_coding
  ENST00000592761 TIMP2-002 78855542-78874136 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262768ENST00000585421ENST00000586057
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262768 121.362±0.00 48.078±0.00 2.877±0.00 21.561±15.67 84.036±52.92 72.388±59.79 24.612±22.04 19.508±18.70 16.977±1.90 88.396±77.42 30.619±0.00 138.046±115.27 292.525±94.85 106.522±39.24
ENST00000585421 83.771±0.00 42.783±0.00 N/A 19.856±16.01 41.889±0.00 69.861±0.00 2.634±0.00 16.338±0.00 N/A N/A 7.455±0.00 152.065±99.10 N/A 124.373±0.00
ENST00000586057 N/A N/A 3.296±0.00 5.201±0.00 N/A N/A N/A 4.563±0.00 10.028±0.00 5.551±0.00 N/A 4.118±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003UE CIL_0003UE_0002 CGP 17:78787381-78925387
CIL_00062J CIL_00062J_0001 CGP 17:78852977-78925387

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005178 IEA integrin binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005604 IEA basement membrane
GO:0005615 IEA extracellular space
GO:0007417 IEA central nervous system development
GO:0007568 IEA aging
GO:0008047 IEA enzyme activator activity
GO:0008191 IEA metalloendopeptidase inhibitor activity
GO:0008285 IEA negative regulation of cell proliferation
GO:0009986 IEA cell surface
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0022617 TAS extracellular matrix disassembly
GO:0030198 TAS extracellular matrix organization
GO:0030426 IEA growth cone
GO:0030814 IEA regulation of cAMP metabolic process
GO:0032487 IEA regulation of Rap protein signal transduction
GO:0034097 IEA response to cytokine
GO:0042493 IEA response to drug
GO:0043005 IEA neuron projection
GO:0043025 IEA neuronal cell body
GO:0043408 IEA regulation of MAPK cascade
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045664 IEA regulation of neuron differentiation
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045762 IEA positive regulation of adenylate cyclase activity
GO:0045861 IEA negative regulation of proteolysis
GO:0045930 IEA negative regulation of mitotic cell cycle
GO:0046580 IEA negative regulation of Ras protein signal transduction
GO:0046872 IEA metal ion binding
GO:0070062 IDA extracellular vesicular exosome
GO:0071310 IEA cellular response to organic substance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061226 timp2a tissue inhibitor of metalloproteinase 2a protein_coding Danio_rerio
ENSDARG00000075261 timp2b tissue inhibitor of metalloproteinase 2b protein_coding Danio_rerio
ENSMUSG00000017466 Timp2 tissue inhibitor of metalloproteinase 2 protein_coding Mus_musculus

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