C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ribonucleotide reductase M2 B (TP53 inducible)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000048392 RRM2B 9606 - 8:102204502-102239118 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000251810 RRM2B-001 102204502-102239118 protein_coding
  ENST00000395910 RRM2B-009 102207776-102214229 retained_intron
  ENST00000395912 RRM2B-005 102208133-102238874 protein_coding
  ENST00000517517 RRM2B-006 102225975-102238797 retained_intron
  ENST00000519125 RRM2B-008 102212776-102219015 retained_intron
  ENST00000519317 RRM2B-004 102208133-102238874 protein_coding
  ENST00000519962 RRM2B-002 102208133-102238874 protein_coding
  ENST00000522368 RRM2B-003 102207745-102238775 protein_coding
  ENST00000522394 RRM2B-011 102208133-102238874 nonsense_mediated_decay
  ENST00000523957 RRM2B-007 102224923-102238939 nonsense_mediated_decay
  ENST00000621845 RRM2B-201 102205625-102238775 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000251810ENST00000395912
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000251810 2.257±0.00 2.979±0.00 0.756±0.00 7.312±2.11 3.021±2.04 3.023±0.20 3.113±1.47 5.094±2.83 2.454±1.24 5.057±2.04 3.669±2.62 3.169±1.00 1.879±0.91 3.106±0.92
ENST00000395912 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.668±0.00 4.100±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00000S CIL_00000S_0001 CGP 8:102204502-102412841

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001822 IEA kidney development
GO:0003014 IEA renal system process
GO:0004748 IEA ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0006264 IEA mitochondrial DNA replication
GO:0006281 IEA DNA repair
GO:0006979 IEA response to oxidative stress
GO:0009186 IEA deoxyribonucleoside diphosphate metabolic process
GO:0009200 IEA deoxyribonucleoside triphosphate metabolic process
GO:0009263 IEA deoxyribonucleotide biosynthetic process
GO:0015949 TAS nucleobase-containing small molecule interconversion
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0055114 IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome
GO:1902254 IEA negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033367 rrm2b ribonucleotide reductase M2 b protein_coding Danio_rerio
ENSMUSG00000022292 Rrm2b ribonucleotide reductase M2 B (TP53 inducible) protein_coding Mus_musculus

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