C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ATPase, Ca++ transporting, plasma membrane 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000058668 ATP2B4 9606 + 1:203626561-203744081 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000341360 ATP2B4-002 203682809-203740319 protein_coding
  ENST00000356729 ATP2B4-006 203723963-203733632 protein_coding
  ENST00000357681 ATP2B4-001 203626561-203744081 protein_coding
  ENST00000367218 ATP2B4-201 203626787-203744079 protein_coding
  ENST00000458092 ATP2B4-004 203723897-203728310 protein_coding
  ENST00000466407 ATP2B4-005 203723961-203727754 processed_transcript
  ENST00000484746 ATP2B4-003 203727468-203744080 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000341360ENST00000357681ENST00000367218ENST00000484746
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000341360 N/A N/A N/A N/A N/A 6.881±0.00 3.112±0.00 1.114±0.00 13.768±0.00 N/A N/A 5.583±0.00 N/A 5.346±0.00
ENST00000357681 19.950±0.00 2.555±0.00 3.235±0.00 N/A 26.882±16.95 N/A 1.625±0.00 3.358±1.26 4.311±1.02 16.961±5.65 0.685±0.09 12.192±10.68 12.100±2.02 3.796±1.33
ENST00000367218 N/A 12.023±0.00 N/A 11.903±0.42 7.555±0.00 18.223±5.15 9.353±5.61 N/A 22.711±0.00 N/A 0.910±0.14 4.586±0.00 N/A 11.006±0.00
ENST00000484746 11.963±0.00 12.676±0.00 N/A 11.391±0.00 39.416±0.00 56.821±0.00 6.961±0.00 6.028±0.00 5.638±0.00 13.387±0.00 1.077±0.00 15.053±8.47 10.778±4.21 12.609±3.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00096T CIL_00096T_0001 VISTA 1:203391843-203993678

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0005388 IMP:IEA calcium-transporting ATPase activity
GO:0005515 IPI protein binding
GO:0005516 IDA calmodulin binding
GO:0005524 IEA ATP binding
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005901 TAS caveola
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0006874 IDA cellular calcium ion homeostasis
GO:0007596 TAS blood coagulation
GO:0008152 IEA metabolic process
GO:0010751 IDA negative regulation of nitric oxide mediated signal transduction
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0017080 ISS sodium channel regulator activity
GO:0030018 IDA Z disc
GO:0030315 IDA T-tubule
GO:0030346 IDA protein phosphatase 2B binding
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0034220 TAS ion transmembrane transport
GO:0036487 IDA nitric-oxide synthase inhibitor activity
GO:0042383 IEA sarcolemma
GO:0043234 ISS protein complex
GO:0045019 IDA negative regulation of nitric oxide biosynthetic process
GO:0046872 IEA metal ion binding
GO:0050998 IPI nitric-oxide synthase binding
GO:0051001 IDA negative regulation of nitric-oxide synthase activity
GO:0051599 IMP response to hydrostatic pressure
GO:0055074 IC calcium ion homeostasis
GO:0055085 TAS transmembrane transport
GO:0070588 IMP:IEA calcium ion transmembrane transport
GO:0070885 IDA negative regulation of calcineurin-NFAT signaling cascade
GO:0071872 IDA cellular response to epinephrine stimulus
GO:0097110 ISS scaffold protein binding
GO:0098703 IC calcium ion import across plasma membrane
GO:0098736 IDA negative regulation of the force of heart contraction
GO:1900082 IDA negative regulation of arginine catabolic process
GO:1901205 IDA negative regulation of adrenergic receptor signaling pathway involved in heart process
GO:1902083 NAS negative regulation of peptidyl-cysteine S-nitrosylation
GO:1902305 IC regulation of sodium ion transmembrane transport
GO:1903243 IMP negative regulation of cardiac muscle hypertrophy in response to stress
GO:1903249 IDA negative regulation of citrulline biosynthetic process
GO:2000481 IDA positive regulation of cAMP-dependent protein kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044902 atp2b4 ATPase, Ca++ transporting, plasma membrane 4 protein_coding Danio_rerio
ENSMUSG00000026463 Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 protein_coding Mus_musculus

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