C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: WNK lysine deficient protein kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000060237 WNK1 9606 + 12:752593-911452 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000315939 WNK1-001 752923-911452 protein_coding
  ENST00000340908 WNK1-201 752923-911452 protein_coding
  ENST00000447667 WNK1-003 753056-827501 protein_coding
  ENST00000530271 WNK1-202 752923-911451 protein_coding
  ENST00000534872 WNK1-008 881764-884688 protein_coding
  ENST00000535572 WNK1-002 752593-911300 protein_coding
  ENST00000535698 WNK1-015 862235-880814 protein_coding
  ENST00000537603 WNK1-013 900473-908201 retained_intron
  ENST00000537687 WNK1-203 752923-911452 protein_coding
  ENST00000538787 WNK1-005 851424-859375 processed_transcript
  ENST00000540360 WNK1-004 829925-861135 processed_transcript
  ENST00000540885 WNK1-011 907720-909033 retained_intron
  ENST00000542424 WNK1-014 896623-901074 retained_intron
  ENST00000542543 WNK1-009 878015-881971 retained_intron
  ENST00000543065 WNK1-017 900598-904487 protein_coding
  ENST00000544559 WNK1-018 900597-907956 protein_coding
  ENST00000544965 WNK1-016 862081-882994 protein_coding
  ENST00000545055 WNK1-010 881471-883419 retained_intron
  ENST00000545285 WNK1-006 862174-880917 protein_coding
  ENST00000574564 WNK1-020 867794-869194 protein_coding
  ENST00000574679 WNK1-019 868568-878312 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000315939ENST00000535572ENST00000537687
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000315939 N/A 1.882±0.00 5.150±0.00 2.906±0.00 2.832±0.00 N/A 13.059±6.47 N/A 4.170±0.00 N/A 2.366±0.00 5.533±2.73 1.317±0.31 9.896±2.34
ENST00000535572 38.425±0.00 6.435±0.00 N/A 14.920±11.77 10.937±7.57 8.744±4.60 10.083±8.01 3.382±0.00 4.222±0.60 6.252±1.36 12.132±9.50 6.867±4.10 5.640±4.25 16.358±5.71
ENST00000537687 N/A N/A N/A 1.282±0.00 N/A N/A N/A N/A N/A N/A 1.615±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008AW CIL_0008AW_0001 VISTA 12:291137-892234
CIL_0007TY CIL_0007TY_0001 VISTA 12:564896-1165613

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003084 IEA positive regulation of systemic arterial blood pressure
GO:0004672 IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004860 IEA protein kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0006468 IDA:IEA protein phosphorylation
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006811 ISS ion transport
GO:0010923 IDA negative regulation of phosphatase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018107 TAS peptidyl-threonine phosphorylation
GO:0019869 IDA chloride channel inhibitor activity
GO:0019902 IDA phosphatase binding
GO:0035556 IDA intracellular signal transduction
GO:0048666 NAS neuron development
GO:0050794 ISS regulation of cellular process
GO:0090188 IEA negative regulation of pancreatic juice secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039392 wnk1b WNK lysine deficient protein kinase 1b protein_coding Danio_rerio
ENSDARG00000078992 wnk1a WNK lysine deficient protein kinase 1a protein_coding Danio_rerio
ENSDARG00000089506 WNK2 WNK lysine deficient protein kinase 1 protein_coding Danio_rerio
ENSMUSG00000045962 Wnk1 WNK lysine deficient protein kinase 1 protein_coding Mus_musculus

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