C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: diacylglycerol O-acyltransferase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000062282 DGAT2 9606 + 11:75759512-75801535 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000228027 DGAT2-001 75768732-75801534 protein_coding
  ENST00000376262 DGAT2-201 75768733-75801535 protein_coding
  ENST00000603276 DGAT2-006 75759512-75797276 protein_coding
  ENST00000603363 DGAT2-004 75792159-75801527 retained_intron
  ENST00000603865 DGAT2-005 75795137-75800632 retained_intron
  ENST00000604733 DGAT2-003 75769001-75800364 protein_coding
  ENST00000604935 DGAT2-007 75768531-75796508 protein_coding
  ENST00000605099 DGAT2-008 75784396-75796511 protein_coding
  ENST00000605608 DGAT2-002 75768799-75774042 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000228027ENST00000376262ENST00000603363ENST00000604733ENST00000604935ENST00000605608
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000228027 14.677±0.00 1.630±0.00 N/A 2.213±0.00 172.491±171.68 3.481±0.00 1.017±0.49 6.827±6.31 11.797±8.13 1.532±0.00 N/A 1.178±0.07 N/A 10.158±0.43
ENST00000376262 N/A N/A N/A N/A N/A 0.916±0.00 N/A N/A N/A 1.011±0.70 0.219±0.00 0.674±0.47 0.465±0.12 N/A
ENST00000603363 N/A N/A N/A 0.080±0.00 N/A 0.309±0.00 N/A N/A N/A 0.269±0.00 N/A 0.370±0.32 0.041±0.00 1.796±0.00
ENST00000604733 12.988±0.00 1.810±0.00 0.138±0.00 1.470±0.00 193.683±192.41 0.524±0.00 N/A N/A 17.635±0.00 5.743±0.00 N/A 1.362±0.22 N/A 12.758±4.43
ENST00000604935 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.197±0.00 N/A N/A N/A
ENST00000605608 N/A N/A 0.101±0.00 N/A N/A N/A N/A N/A N/A N/A 1.644±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NG CIL_0008NG_0001 VISTA 11:75253021-75855707
CIL_000927 CIL_000927_0001 VISTA 11:75746993-76349575

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003846 IEA 2-acylglycerol O-acyltransferase activity
GO:0004144 IDA diacylglycerol O-acyltransferase activity
GO:0005739 ISS mitochondrion
GO:0005783 IDA endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005811 ISS lipid particle
GO:0006071 IEA glycerol metabolic process
GO:0006644 TAS phospholipid metabolic process
GO:0008152 IEA metabolic process
GO:0016020 IEA membrane
GO:0016021 IDA integral component of membrane
GO:0016747 IEA transferase activity, transferring acyl groups other than amino-acyl groups
GO:0019432 IEA triglyceride biosynthetic process
GO:0019915 ISS lipid storage
GO:0030176 ISS integral component of endoplasmic reticulum membrane
GO:0034383 ISS low-density lipoprotein particle clearance
GO:0035336 IDA long-chain fatty-acyl-CoA metabolic process
GO:0035356 ISS cellular triglyceride homeostasis
GO:0036155 TAS acylglycerol acyl-chain remodeling
GO:0042572 IEA retinol metabolic process
GO:0042632 ISS cholesterol homeostasis
GO:0042803 ISS protein homodimerization activity
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0046339 IDA diacylglycerol metabolic process
GO:0046474 TAS glycerophospholipid biosynthetic process
GO:0048471 ISS perinuclear region of cytoplasm
GO:0050252 IEA retinol O-fatty-acyltransferase activity
GO:0055089 ISS fatty acid homeostasis
GO:0060613 ISS fat pad development
GO:0071400 ISS cellular response to oleic acid
GO:0097006 ISS regulation of plasma lipoprotein particle levels

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018846 dgat2 diacylglycerol O-acyltransferase 2 protein_coding Danio_rerio
ENSMUSG00000030747 Dgat2 diacylglycerol O-acyltransferase 2 protein_coding Mus_musculus

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