C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibroblast growth factor receptor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000066468 FGFR2 9606 - 10:121478334-121598458 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000336553 FGFR2-003 121483718-121598396 protein_coding
  ENST00000346997 FGFR2-009 121479857-121593829 protein_coding
  ENST00000351936 FGFR2-201 121479857-121593829 protein_coding
  ENST00000356226 FGFR2-012 121479072-121598458 protein_coding
  ENST00000357555 FGFR2-202 121478334-121596645 protein_coding
  ENST00000358487 FGFR2-001 121478341-121598084 protein_coding
  ENST00000359354 FGFR2-016 121537966-121598298 protein_coding
  ENST00000360144 FGFR2-004 121481835-121598432 protein_coding
  ENST00000369056 FGFR2-006 121481856-121593841 protein_coding
  ENST00000369058 FGFR2-011 121483698-121598234 protein_coding
  ENST00000369059 FGFR2-007 121479619-121598452 protein_coding
  ENST00000369060 FGFR2-005 121479218-121598298 protein_coding
  ENST00000369061 FGFR2-203 121478334-121593967 protein_coding
  ENST00000429361 FGFR2-021 121479855-121515179 protein_coding
  ENST00000457416 FGFR2-010 121479857-121598403 protein_coding
  ENST00000463870 FGFR2-023 121515227-121518829 processed_transcript
  ENST00000467584 FGFR2-020 121479785-121480485 processed_transcript
  ENST00000478859 FGFR2-008 121478364-121531314 protein_coding
  ENST00000490349 FGFR2-015 121517334-121598072 processed_transcript
  ENST00000491111 FGFR2-013 121583302-121594153 processed_transcript
  ENST00000491475 FGFR2-022 121564324-121565911 retained_intron
  ENST00000604236 FGFR2-024 121479227-121598413 nonsense_mediated_decay
  ENST00000611527 FGFR2-026 121564324-121593887 protein_coding
  ENST00000613048 FGFR2-204 121478334-121598458 protein_coding
  ENST00000613324 FGFR2-025 121564324-121593764 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000336553ENST00000346997ENST00000351936ENST00000356226ENST00000357555ENST00000358487ENST00000359354ENST00000360144ENST00000369058ENST00000369059ENST00000369060ENST00000369061ENST00000429361ENST00000457416ENST00000490349ENST00000604236ENST00000613048
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000336553 N/A N/A N/A 10.270±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000346997 N/A N/A N/A 11.503±0.00 N/A 1.716±0.00 N/A N/A N/A N/A N/A 2.083±1.30 N/A 1.765±0.50
ENST00000351936 N/A N/A N/A N/A N/A N/A N/A N/A 1.820±0.00 N/A N/A N/A N/A N/A
ENST00000356226 N/A N/A N/A 4.598±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000357555 N/A N/A N/A N/A N/A N/A 0.031±0.00 N/A N/A N/A N/A 0.498±0.00 N/A N/A
ENST00000358487 0.168±0.00 0.611±0.00 N/A 5.762±1.73 N/A 3.446±1.71 N/A 4.868±0.82 N/A 0.588±0.00 N/A 2.196±0.94 4.545±0.00 1.395±0.00
ENST00000359354 N/A N/A N/A N/A 4.617±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000360144 N/A 0.351±0.00 N/A N/A N/A N/A N/A N/A N/A 0.680±0.00 0.049±0.00 N/A N/A N/A
ENST00000369058 N/A N/A 1.593±0.00 N/A N/A N/A 0.103±0.00 2.762±0.00 N/A N/A N/A 1.122±0.00 2.452±0.00 N/A
ENST00000369059 N/A N/A 1.498±0.00 N/A N/A 2.124±0.00 N/A N/A N/A 0.898±0.00 N/A 2.135±0.00 1.121±0.04 N/A
ENST00000369060 N/A N/A N/A N/A N/A N/A N/A N/A 1.620±0.00 N/A N/A N/A N/A N/A
ENST00000369061 0.210±0.00 N/A N/A 2.630±0.00 N/A N/A N/A 1.420±0.00 1.477±0.00 N/A N/A N/A N/A N/A
ENST00000429361 0.472±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000457416 N/A N/A 0.996±0.00 N/A 3.980±0.00 1.617±0.00 N/A N/A N/A 3.108±0.00 N/A N/A N/A N/A
ENST00000490349 N/A N/A 2.160±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000604236 N/A N/A N/A N/A N/A N/A 0.089±0.00 N/A N/A 2.055±0.00 N/A N/A N/A N/A
ENST00000613048 N/A 0.335±0.00 N/A 5.702±0.00 1.951±0.35 3.731±2.39 N/A 4.101±0.00 2.014±0.94 N/A N/A 2.725±1.08 1.078±0.45 1.460±0.35

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002WI CIL_0002WI_0001 CGP 10:120851175-121598458
CIL_0007TN CIL_0007TN_0001 VISTA 10:121051688-121653399
CIL_0001BE CIL_0001BE_0001 CGP 10:121478334-121928801

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001525 ISS angiogenesis
GO:0001657 ISS ureteric bud development
GO:0001701 ISS in utero embryonic development
GO:0001837 IEA epithelial to mesenchymal transition
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0003148 ISS outflow tract septum morphogenesis
GO:0003149 ISS membranous septum morphogenesis
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005007 IEA fibroblast growth factor-activated receptor activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005576 IEA extracellular region
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005938 IDA cell cortex
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007267 ISS cell-cell signaling
GO:0007409 ISS axonogenesis
GO:0007528 IEA neuromuscular junction development
GO:0008201 IEA heparin binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 IEA fibroblast growth factor receptor signaling pathway
GO:0008589 ISS regulation of smoothened signaling pathway
GO:0009791 ISS post-embryonic development
GO:0009880 ISS embryonic pattern specification
GO:0009887 ISS organ morphogenesis
GO:0009986 IDA cell surface
GO:0010453 ISS regulation of cell fate commitment
GO:0010518 IMP positive regulation of phospholipase activity
GO:0016020 NAS membrane
GO:0016021 IEA integral component of membrane
GO:0016331 ISS morphogenesis of embryonic epithelium
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017134 IPI fibroblast growth factor binding
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0021769 ISS orbitofrontal cortex development
GO:0021847 ISS ventricular zone neuroblast division
GO:0021860 ISS pyramidal neuron development
GO:0022612 ISS gland morphogenesis
GO:0030177 ISS positive regulation of Wnt signaling pathway
GO:0030282 ISS bone mineralization
GO:0030324 ISS lung development
GO:0030855 ISS epithelial cell differentiation
GO:0030901 ISS midbrain development
GO:0030916 ISS otic vesicle formation
GO:0031012 IDA extracellular matrix
GO:0031069 ISS hair follicle morphogenesis
GO:0031410 IEA cytoplasmic vesicle
GO:0032808 ISS lacrimal gland development
GO:0033688 TAS regulation of osteoblast proliferation
GO:0035264 ISS multicellular organism growth
GO:0035265 ISS organ growth
GO:0035602 ISS fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow
GO:0035603 ISS fibroblast growth factor receptor signaling pathway involved in hemopoiesis
GO:0035604 ISS fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
GO:0035607 ISS fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0040014 ISS regulation of multicellular organism growth
GO:0040036 ISS regulation of fibroblast growth factor receptor signaling pathway
GO:0042127 IEA regulation of cell proliferation
GO:0042472 ISS inner ear morphogenesis
GO:0042476 ISS odontogenesis
GO:0042803 IPI protein homodimerization activity
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043410 IMP positive regulation of MAPK cascade
GO:0045087 TAS innate immune response
GO:0045165 ISS cell fate commitment
GO:0045667 TAS regulation of osteoblast differentiation
GO:0045787 ISS positive regulation of cell cycle
GO:0045839 IEA negative regulation of mitosis
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046777 IDA protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048286 ISS lung alveolus development
GO:0048333 IEA mesodermal cell differentiation
GO:0048489 IEA synaptic vesicle transport
GO:0048557 ISS embryonic digestive tract morphogenesis
GO:0048562 ISS embryonic organ morphogenesis
GO:0048565 ISS digestive tract development
GO:0048568 ISS embryonic organ development
GO:0048608 ISS reproductive structure development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0048705 TAS skeletal system morphogenesis
GO:0048730 ISS epidermis morphogenesis
GO:0048755 ISS branching morphogenesis of a nerve
GO:0048762 ISS mesenchymal cell differentiation
GO:0050673 IEA epithelial cell proliferation
GO:0050678 IEA regulation of epithelial cell proliferation
GO:0050679 ISS positive regulation of epithelial cell proliferation
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0051150 ISS regulation of smooth muscle cell differentiation
GO:0051781 ISS positive regulation of cell division
GO:0055010 ISS ventricular cardiac muscle tissue morphogenesis
GO:0060045 ISS positive regulation of cardiac muscle cell proliferation
GO:0060076 ISS excitatory synapse
GO:0060174 ISS limb bud formation
GO:0060348 ISS bone development
GO:0060349 ISS bone morphogenesis
GO:0060365 IEA coronal suture morphogenesis
GO:0060441 IEA epithelial tube branching involved in lung morphogenesis
GO:0060442 ISS branching involved in prostate gland morphogenesis
GO:0060445 ISS branching involved in salivary gland morphogenesis
GO:0060449 ISS bud elongation involved in lung branching
GO:0060463 ISS lung lobe morphogenesis
GO:0060484 ISS lung-associated mesenchyme development
GO:0060501 ISS positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060512 ISS prostate gland morphogenesis
GO:0060523 ISS prostate epithelial cord elongation
GO:0060527 ISS prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060529 ISS squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0060595 ISS fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060601 ISS lateral sprouting from an epithelium
GO:0060615 ISS mammary gland bud formation
GO:0060664 ISS epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060667 ISS branch elongation involved in salivary gland morphogenesis
GO:0060670 ISS branching involved in labyrinthine layer morphogenesis
GO:0060687 ISS regulation of branching involved in prostate gland morphogenesis
GO:0060688 ISS regulation of morphogenesis of a branching structure
GO:0060915 ISS mesenchymal cell differentiation involved in lung development
GO:0060916 ISS mesenchymal cell proliferation involved in lung development
GO:0061031 IEA endodermal digestive tract morphogenesis
GO:0070307 IEA lens fiber cell development
GO:0070372 ISS regulation of ERK1 and ERK2 cascade
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0090263 ISS positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058115 fgfr2 fibroblast growth factor receptor 2 protein_coding Danio_rerio
ENSMUSG00000030849 Fgfr2 fibroblast growth factor receptor 2 protein_coding Mus_musculus

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