C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyruvate dehydrogenase kinase, isozyme 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000067992 PDK3 9606 + X:24465221-24539837 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000379162 PDK3-001 24465221-24534425 protein_coding
  ENST00000441463 PDK3-003 24465456-24539837 protein_coding
  ENST00000493226 PDK3-002 24494741-24499081 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000379162ENST00000441463
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000379162 N/A 0.908±0.00 N/A N/A N/A 1.085±0.23 N/A 0.914±0.05 0.830±0.40 1.011±0.32 0.068±0.00 N/A 0.437±0.01 N/A
ENST00000441463 2.551±0.00 2.976±0.00 12.174±0.00 4.874±3.88 3.462±2.68 5.417±2.84 0.426±0.16 2.064±0.60 3.356±0.75 3.549±0.60 1.090±0.80 5.532±3.88 3.125±0.61 13.547±5.28

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00084H CIL_00084H_0001 VISTA X:24441239-25041771

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004740 IDA pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005739 TAS mitochondrion
GO:0005759 TAS mitochondrial matrix
GO:0006006 IEA glucose metabolic process
GO:0006090 TAS pyruvate metabolic process
GO:0008219 IEA cell death
GO:0010510 IMP regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906 IMP regulation of glucose metabolic process
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0035357 IMP peroxisome proliferator activated receptor signaling pathway
GO:0044237 TAS cellular metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0071333 ISS cellular response to glucose stimulus
GO:0071398 IMP cellular response to fatty acid
GO:0097411 IMP hypoxia-inducible factor-1alpha signaling pathway
GO:2000377 IMP regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014527 pdk3a pyruvate dehydrogenase kinase, isozyme 3a protein_coding Danio_rerio
ENSDARG00000060460 pdk3b pyruvate dehydrogenase kinase, isozyme 3b protein_coding Danio_rerio
ENSMUSG00000035232 Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 protein_coding Mus_musculus

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