C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transforming growth factor, beta receptor III
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000069702 TGFBR3 9606 - 1:91680343-91906335 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000212355 TGFBR3-201 91680345-91886279 protein_coding
  ENST00000370399 TGFBR3-001 91682426-91906335 protein_coding
  ENST00000417833 TGFBR3-009 91797427-91886122 protein_coding
  ENST00000465892 TGFBR3-002 91683729-91886109 protein_coding
  ENST00000468996 TGFBR3-004 91727777-91766432 processed_transcript
  ENST00000470600 TGFBR3-005 91695490-91712363 retained_intron
  ENST00000525962 TGFBR3-006 91682430-91861593 protein_coding
  ENST00000529608 TGFBR3-010 91719893-91727918 retained_intron
  ENST00000532540 TGFBR3-008 91682647-91885932 nonsense_mediated_decay
  ENST00000533089 TGFBR3-007 91680343-91862046 nonsense_mediated_decay
  ENST00000533370 TGFBR3-003 91863839-91886151 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000212355ENST00000465892ENST00000532540
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000212355 41.466±0.00 5.845±0.00 N/A 0.838±0.07 9.879±2.53 9.559±7.69 3.820±1.78 3.289±1.46 4.815±3.67 16.557±9.15 3.066±0.00 16.003±20.85 7.588±0.07 3.345±1.97
ENST00000465892 N/A N/A 7.189±0.00 0.611±0.00 4.172±0.00 3.487±0.00 1.297±0.00 1.345±0.00 16.486±0.00 7.240±0.00 2.149±0.00 7.283±0.00 N/A N/A
ENST00000532540 N/A N/A N/A N/A N/A 2.005±0.00 N/A N/A N/A N/A 1.044±0.00 0.706±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00069I CIL_00069I_0001 CGP 1:91500893-91906335
CIL_0008DI CIL_0008DI_0001 VISTA 1:91505983-92108430
CIL_0008YV CIL_0008YV_0001 VISTA 1:91545179-92146674
CIL_0005ZR CIL_0005ZR_0001 CGP 1:91680343-92014426

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001568 IEA blood vessel development
GO:0001666 IEA response to hypoxia
GO:0001701 IEA in utero embryonic development
GO:0001824 IEA blastocyst development
GO:0001837 IDA epithelial to mesenchymal transition
GO:0001889 ISS liver development
GO:0003007 ISS heart morphogenesis
GO:0005024 IDA transforming growth factor beta-activated receptor activity
GO:0005114 IDA type II transforming growth factor beta receptor binding
GO:0005160 ISS transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005539 ISS glycosaminoglycan binding
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0005737 IEA cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005887 ISS integral component of plasma membrane
GO:0006461 IEA protein complex assembly
GO:0006955 IMP immune response
GO:0007179 IMP transforming growth factor beta receptor signaling pathway
GO:0007181 IEA transforming growth factor beta receptor complex assembly
GO:0008201 ISS heparin binding
GO:0009897 IDA external side of plasma membrane
GO:0009986 ISS cell surface
GO:0010633 IEA negative regulation of epithelial cell migration
GO:0010719 IEA negative regulation of epithelial to mesenchymal transition
GO:0015026 IDA coreceptor activity
GO:0016049 ISS cell growth
GO:0016477 ISS cell migration
GO:0017134 IEA fibroblast growth factor binding
GO:0030165 ISS PDZ domain binding
GO:0030509 IDA BMP signaling pathway
GO:0030511 IEA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 IEA organ regeneration
GO:0032354 IDA response to follicle-stimulating hormone
GO:0034673 IDA inhibin-betaglycan-ActRII complex
GO:0034695 IDA response to prostaglandin E
GO:0034699 IDA response to luteinizing hormone
GO:0035556 IMP intracellular signal transduction
GO:0043393 IEA regulation of protein binding
GO:0046332 IMP SMAD binding
GO:0048185 IEA activin binding
GO:0050431 IDA transforming growth factor beta binding
GO:0050680 ISS negative regulation of epithelial cell proliferation
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051271 IDA negative regulation of cellular component movement
GO:0055010 ISS ventricular cardiac muscle tissue morphogenesis
GO:0060021 ISS palate development
GO:0060038 ISS cardiac muscle cell proliferation
GO:0060216 ISS definitive hemopoiesis
GO:0060317 IDA cardiac epithelial to mesenchymal transition
GO:0060318 ISS definitive erythrocyte differentiation
GO:0060347 ISS heart trabecula formation
GO:0060389 IMP pathway-restricted SMAD protein phosphorylation
GO:0070062 IDA extracellular vesicular exosome
GO:0070123 IDA transforming growth factor beta receptor activity, type III

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078670 tgfbr3 transforming growth factor, beta receptor III protein_coding Danio_rerio
ENSMUSG00000029287 Tgfbr3 transforming growth factor, beta receptor III protein_coding Mus_musculus

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