C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NCK adaptor protein 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000071051 NCK2 9606 + 2:105744897-105894274 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000233154 NCK2-001 105744897-105894274 protein_coding
  ENST00000393348 NCK2-004 105745731-105881534 protein_coding
  ENST00000393349 NCK2-002 105851782-105894272 protein_coding
  ENST00000425756 NCK2-003 105851748-105881432 protein_coding
  ENST00000451463 NCK2-201 105745063-105894274 protein_coding
  ENST00000522586 NCK2-005 105816558-105893176 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000233154ENST00000393349ENST00000451463
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000233154 11.057±0.00 8.834±0.00 1.908±0.00 9.078±0.00 4.927±2.97 5.399±4.34 7.358±6.31 7.590±7.25 2.630±0.30 10.669±8.17 6.268±5.04 15.967±9.08 22.589±6.83 12.029±3.24
ENST00000393349 6.624±0.00 10.979±0.00 0.588±0.00 3.624±0.78 7.350±0.00 11.367±0.00 0.315±0.00 N/A 1.035±0.00 9.495±0.00 N/A 12.586±0.00 6.170±0.00 6.751±0.00
ENST00000451463 N/A N/A N/A 3.694±0.00 1.061±0.00 N/A N/A N/A N/A N/A 1.866±0.00 2.577±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00010G CIL_00010G_0001 CGP 2:105357712-105894274
CIL_0003Y7 CIL_0003Y7_0001 CGP 2:105744897-106078159

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005737 NAS cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0006417 IEA regulation of translation
GO:0007015 IEA actin filament organization
GO:0007165 TAS signal transduction
GO:0007172 NAS signal complex assembly
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007176 TAS regulation of epidermal growth factor-activated receptor activity
GO:0007411 TAS axon guidance
GO:0008093 NAS cytoskeletal adaptor activity
GO:0008285 TAS negative regulation of cell proliferation
GO:0012506 IEA vesicle membrane
GO:0016477 IEA cell migration
GO:0030032 IEA lamellipodium assembly
GO:0030159 NAS receptor signaling complex scaffold activity
GO:0030838 IMP positive regulation of actin filament polymerization
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042110 NAS T cell activation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018206 nck2a NCK adaptor protein 2a protein_coding Danio_rerio
ENSDARG00000043361 nck2b NCK adaptor protein 2b protein_coding Danio_rerio
ENSMUSG00000066877 Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 protein_coding Mus_musculus

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