C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000071054 MAP4K4 9606 + 2:101696850-101894689 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302217 MAP4K4-201 101698026-101894689 protein_coding
  ENST00000324219 MAP4K4-202 101697703-101894689 protein_coding
  ENST00000347699 MAP4K4-001 101698081-101891321 protein_coding
  ENST00000350198 MAP4K4-203 101697703-101894689 protein_coding
  ENST00000350878 MAP4K4-204 101697703-101894689 protein_coding
  ENST00000413150 MAP4K4-003 101698026-101894687 protein_coding
  ENST00000417294 MAP4K4-004 101698530-101891987 protein_coding
  ENST00000418101 MAP4K4-011 101855977-101865003 protein_coding
  ENST00000421882 MAP4K4-006 101839828-101891496 protein_coding
  ENST00000425019 MAP4K4-002 101697744-101891496 protein_coding
  ENST00000427603 MAP4K4-008 101696850-101824053 protein_coding
  ENST00000456652 MAP4K4-005 101698081-101891987 protein_coding
  ENST00000476609 MAP4K4-007 101825402-101862240 retained_intron
  ENST00000477711 MAP4K4-012 101866493-101867730 retained_intron
  ENST00000489490 MAP4K4-010 101825319-101829754 retained_intron
  ENST00000491743 MAP4K4-014 101867856-101870085 retained_intron
  ENST00000496989 MAP4K4-009 101797234-101831816 processed_transcript
  ENST00000498066 MAP4K4-013 101867536-101870633 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302217ENST00000324219ENST00000347699ENST00000350198ENST00000350878ENST00000413150ENST00000417294ENST00000421882ENST00000425019ENST00000427603ENST00000456652
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302217 N/A 6.826±0.00 N/A 7.252±0.00 7.690±0.00 3.002±2.33 5.843±0.00 1.900±0.00 0.910±0.00 N/A 5.008±0.00 2.997±0.47 3.299±0.07 8.168±0.00
ENST00000324219 N/A N/A N/A N/A N/A N/A 5.064±0.00 N/A N/A N/A N/A N/A N/A 7.532±0.00
ENST00000347699 N/A N/A 1.105±0.00 N/A 3.009±0.00 0.805±0.00 1.496±0.00 1.924±0.00 N/A 3.117±0.00 N/A 5.385±0.00 N/A N/A
ENST00000350198 N/A N/A N/A N/A N/A N/A N/A 1.489±0.00 0.763±0.00 N/A N/A N/A N/A N/A
ENST00000350878 N/A N/A N/A N/A N/A 0.448±0.00 N/A N/A N/A 2.236±0.00 N/A 3.904±0.43 9.960±0.00 6.407±0.39
ENST00000413150 8.169±0.00 3.765±0.00 N/A 14.667±0.00 3.114±1.38 3.221±2.57 N/A 1.567±0.00 N/A N/A N/A 3.630±1.95 4.399±0.55 6.461±0.00
ENST00000417294 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 14.803±0.00 15.294±0.00 16.575±0.00
ENST00000421882 N/A N/A N/A 16.788±0.00 N/A N/A N/A N/A 2.864±0.00 7.563±0.00 N/A 4.261±0.00 N/A 11.558±0.00
ENST00000425019 25.616±0.00 11.624±0.00 1.219±0.00 10.692±3.59 6.014±1.85 5.157±2.93 6.486±4.60 4.278±0.01 4.817±0.63 8.822±0.00 6.998±0.00 7.615±1.95 5.947±0.20 N/A
ENST00000427603 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.739±0.00 N/A N/A N/A
ENST00000456652 N/A N/A N/A N/A N/A N/A N/A N/A 1.730±0.00 N/A N/A N/A 6.468±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004QW CIL_0004QW_0001 CGP 2:101696850-102028544

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005083 IEA small GTPase regulator activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0006468 IEA protein phosphorylation
GO:0010977 IEA negative regulation of neuron projection development
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0035556 IDA intracellular signal transduction
GO:0046328 IDA regulation of JNK cascade
GO:0050790 IEA regulation of catalytic activity
GO:0061179 IEA negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070571 IEA negative regulation of neuron projection regeneration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000093661 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 protein_coding Danio_rerio
ENSMUSG00000026074 Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 protein_coding Mus_musculus

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