C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase, cAMP-dependent, catalytic, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000072062 PRKACA 9606 - 19:14091688-14118084 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308677 PRKACA-001 14091688-14117744 protein_coding
  ENST00000350356 PRKACA-005 14091697-14108390 processed_transcript
  ENST00000536649 PRKACA-004 14096971-14112647 retained_intron
  ENST00000587372 PRKACA-010 14093043-14106860 protein_coding
  ENST00000587533 PRKACA-007 14096371-14098465 retained_intron
  ENST00000588209 PRKACA-009 14093650-14101278 retained_intron
  ENST00000589284 PRKACA-008 14102901-14118084 protein_coding
  ENST00000589994 PRKACA-003 14093050-14114188 protein_coding
  ENST00000590853 PRKACA-002 14092036-14117732 protein_coding
  ENST00000593092 PRKACA-006 14097248-14107404 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000308677ENST00000587372ENST00000589994ENST00000590853ENST00000593092
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000308677 40.011±0.00 32.855±0.00 15.250±10.85 18.985±17.00 12.446±11.81 28.390±24.59 17.640±0.00 9.018±7.86 24.030±22.88 19.333±10.61 16.183±15.33 10.860±4.62 24.525±13.56
ENST00000587372 25.549±0.00 N/A 26.456±0.00 28.212±0.00 N/A N/A 10.795±0.00 N/A N/A N/A N/A N/A 28.425±0.00
ENST00000589994 24.069±0.00 N/A 19.828±0.00 12.812±6.74 9.987±5.17 26.859±20.72 7.769±3.94 3.314±0.00 4.245±0.00 12.210±0.00 42.696±37.30 5.845±0.00 17.295±2.90
ENST00000590853 N/A N/A N/A N/A N/A N/A N/A 11.411±0.00 N/A N/A N/A N/A N/A
ENST00000593092 N/A N/A N/A N/A N/A 3.163±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0001707 IEA mesoderm formation
GO:0001843 IEA neural tube closure
GO:0002027 TAS regulation of heart rate
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004691 ISS cAMP-dependent protein kinase activity
GO:0004712 IDA protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0005952 NAS cAMP-dependent protein kinase complex
GO:0005975 TAS carbohydrate metabolic process
GO:0006006 TAS glucose metabolic process
GO:0006094 TAS gluconeogenesis
GO:0006112 TAS energy reserve metabolic process
GO:0006468 NAS:IEA protein phosphorylation
GO:0006833 TAS water transport
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007596 TAS blood coagulation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010881 TAS regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016020 IDA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0019433 TAS triglyceride catabolic process
GO:0019901 IPI protein kinase binding
GO:0031514 IEA motile cilium
GO:0031588 IDA AMP-activated protein kinase complex
GO:0031594 IEA neuromuscular junction
GO:0031625 IDA ubiquitin protein ligase binding
GO:0034199 TAS activation of protein kinase A activity
GO:0034237 IPI protein kinase A regulatory subunit binding
GO:0034704 TAS calcium channel complex
GO:0035556 TAS intracellular signal transduction
GO:0035584 TAS calcium-mediated signaling using intracellular calcium source
GO:0043393 TAS regulation of protein binding
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045667 IDA regulation of osteoblast differentiation
GO:0046777 IEA protein autophosphorylation
GO:0046827 IEA positive regulation of protein export from nucleus
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048240 ISS sperm capacitation
GO:0050796 TAS regulation of insulin secretion
GO:0050804 IEA regulation of synaptic transmission
GO:0051480 TAS cytosolic calcium ion homeostasis
GO:0055085 TAS transmembrane transport
GO:0055117 TAS regulation of cardiac muscle contraction
GO:0060314 TAS regulation of ryanodine-sensitive calcium-release channel activity
GO:0061136 IDA regulation of proteasomal protein catabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:0070613 IEA regulation of protein processing
GO:0071158 ISS positive regulation of cell cycle arrest
GO:0071333 IDA cellular response to glucose stimulus
GO:0071374 IEA cellular response to parathyroid hormone stimulus
GO:0071377 TAS cellular response to glucagon stimulus
GO:0071872 TAS cellular response to epinephrine stimulus
GO:0086064 TAS cell communication by electrical coupling involved in cardiac conduction
GO:0097225 IDA sperm midpiece
GO:0097546 IEA ciliary base
GO:1901621 IEA negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:2000810 IDA regulation of tight junction assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068026 CABZ01071153.1 protein kinase, cAMP-dependent, catalytic, alpha protein_coding Danio_rerio
ENSMUSG00000005469 Prkaca protein kinase, cAMP dependent, catalytic, alpha protein_coding Mus_musculus

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