C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000079246 XRCC5 9606 + 2:216107464-216206303 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000392132 XRCC5-201 216109297-216206291 protein_coding
  ENST00000392133 XRCC5-001 216107464-216206303 protein_coding
  ENST00000417391 XRCC5-003 216109351-216119108 protein_coding
  ENST00000429133 XRCC5-005 216109331-216119139 processed_transcript
  ENST00000451695 XRCC5-006 216113092-216119165 nonsense_mediated_decay
  ENST00000460284 XRCC5-010 216116885-216205423 retained_intron
  ENST00000471649 XRCC5-008 216130710-216141319 processed_transcript
  ENST00000476360 XRCC5-004 216109342-216117038 retained_intron
  ENST00000485763 XRCC5-009 216204016-216205422 retained_intron
  ENST00000493706 XRCC5-007 216125923-216127990 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000392132ENST00000460284ENST00000485763
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000392132 60.228±0.00 58.191±0.00 7.387±0.00 34.204±16.28 25.731±11.53 31.561±18.14 16.554±12.65 29.841±15.03 16.560±1.29 27.648±19.13 24.299±17.41 44.740±16.85 49.814±11.03 63.418±7.68
ENST00000460284 N/A N/A 2.904±0.00 N/A 5.192±0.00 2.366±0.00 1.478±0.00 N/A 3.563±0.00 3.191±0.00 N/A 6.983±0.00 N/A N/A
ENST00000485763 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 77.795±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005ME CIL_0005ME_0001 CGP 2:216081866-216206303
CIL_0000AO CIL_0000AO_0002 CGP 2:216107464-216372027

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000723 IEA:TAS telomere maintenance
GO:0000783 TAS nuclear telomere cap complex
GO:0000784 IDA nuclear chromosome, telomeric region
GO:0003677 NAS:IEA DNA binding
GO:0003684 IEA damaged DNA binding
GO:0003690 TAS double-stranded DNA binding
GO:0003691 IDA double-stranded telomeric DNA binding
GO:0004003 IEA ATP-dependent DNA helicase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006281 TAS DNA repair
GO:0006302 TAS double-strand break repair
GO:0006303 IEA:TAS double-strand break repair via nonhomologous end joining
GO:0006310 IEA DNA recombination
GO:0006351 IEA transcription, DNA-templated
GO:0007420 IEA brain development
GO:0008022 IPI protein C-terminus binding
GO:0008283 IEA cell proliferation
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016817 IEA hydrolase activity, acting on acid anhydrides
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032481 TAS positive regulation of type I interferon production
GO:0032508 IEA DNA duplex unwinding
GO:0042162 IEA:IDA telomeric DNA binding
GO:0042493 IEA response to drug
GO:0043234 IEA protein complex
GO:0043564 IEA:IDA Ku70:Ku80 complex
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044822 IDA poly(A) RNA binding
GO:0045087 TAS innate immune response
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0050769 IEA positive regulation of neurogenesis
GO:0051575 IMP 5'-deoxyribose-5-phosphate lyase activity
GO:0060218 IEA hematopoietic stem cell differentiation
GO:0070419 IDA nonhomologous end joining complex
GO:0071398 IEA cellular response to fatty acid
GO:0071475 IEA cellular hyperosmotic salinity response
GO:0071481 IEA cellular response to X-ray
GO:0075713 TAS establishment of integrated proviral latency

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015599 xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 protein_coding Danio_rerio
ENSDARG00000068862 xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 protein_coding Danio_rerio
ENSMUSG00000026187 Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 protein_coding Mus_musculus

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