C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000084774 CAD 9606 + 2:27217390-27243943 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264705 CAD-001 27217390-27243943 protein_coding
  ENST00000403525 CAD-002 27217408-27243785 protein_coding
  ENST00000428460 CAD-011 27241921-27243590 protein_coding
  ENST00000456311 CAD-004 27239118-27241951 protein_coding
  ENST00000458503 CAD-008 27235633-27238178 protein_coding
  ENST00000464159 CAD-003 27227501-27232643 processed_transcript
  ENST00000475695 CAD-006 27233079-27234135 retained_intron
  ENST00000479002 CAD-007 27234596-27235876 retained_intron
  ENST00000487239 CAD-009 27239152-27240222 retained_intron
  ENST00000491461 CAD-010 27239331-27240218 processed_transcript
  ENST00000491891 CAD-005 27226224-27231572 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264705ENST00000403525ENST00000428460ENST00000456311
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264705 1.624±0.00 2.043±0.00 N/A 0.856±0.11 1.180±0.00 0.999±0.44 0.370±0.00 1.903±0.00 0.479±0.10 0.170±0.00 1.337±0.00 3.185±2.28 2.021±0.36 1.870±0.43
ENST00000403525 1.069±0.00 1.736±0.00 0.673±0.00 1.117±0.00 1.232±0.37 0.678±0.00 0.755±0.00 0.561±0.41 0.810±0.00 1.179±0.32 N/A 3.904±2.08 1.690±0.80 2.769±0.24
ENST00000428460 N/A 9.720±0.00 N/A N/A 6.012±0.00 5.416±0.00 N/A N/A 3.441±0.00 5.417±0.00 3.322±0.00 N/A 3.997±0.00 8.978±0.00
ENST00000456311 N/A N/A N/A N/A 4.721±0.00 N/A N/A N/A N/A 4.603±0.00 N/A N/A N/A 8.750±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000EH CIL_0000EH_0001 CGP 2:27212027-27243943
CIL_0000EG CIL_0000EG_0001 CGP 2:27217390-27275817

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001889 IEA liver development
GO:0003824 IEA catalytic activity
GO:0004070 ISS:IEA aspartate carbamoyltransferase activity
GO:0004088 ISS carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151 ISS dihydroorotase activity
GO:0004672 ISS protein kinase activity
GO:0005524 ISS:IEA ATP binding
GO:0005634 IDA nucleus
GO:0005829 IDA cytosol
GO:0006206 TAS pyrimidine nucleobase metabolic process
GO:0006207 ISS:IEA 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006228 IEA UTP biosynthetic process
GO:0006520 IEA cellular amino acid metabolic process
GO:0006541 ISS glutamine metabolic process
GO:0006543 IEA glutamine catabolic process
GO:0006807 IEA nitrogen compound metabolic process
GO:0007507 IEA heart development
GO:0007565 IEA female pregnancy
GO:0007595 IEA lactation
GO:0008152 IEA metabolic process
GO:0008270 IDA zinc ion binding
GO:0008716 IEA D-alanine-D-alanine ligase activity
GO:0014075 IEA response to amine
GO:0016020 IDA membrane
GO:0016363 IDA nuclear matrix
GO:0016597 IEA amino acid binding
GO:0016743 IEA carboxyl- or carbamoyltransferase activity
GO:0016787 IEA hydrolase activity
GO:0016810 IEA hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 IEA hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0017144 ISS drug metabolic process
GO:0018107 ISS peptidyl-threonine phosphorylation
GO:0019899 IPI enzyme binding
GO:0031000 IEA response to caffeine
GO:0031100 IEA organ regeneration
GO:0033574 IEA response to testosterone
GO:0035690 IEA cellular response to drug
GO:0042802 ISS identical protein binding
GO:0042995 ISS cell projection
GO:0043025 ISS neuronal cell body
GO:0043195 ISS terminal bouton
GO:0043234 IEA protein complex
GO:0044205 IEA 'de novo' UMP biosynthetic process
GO:0044281 TAS small molecule metabolic process
GO:0046134 TAS pyrimidine nucleoside biosynthetic process
GO:0046777 ISS protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0051414 IEA response to cortisol
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:0070335 ISS aspartate binding
GO:0070409 IEA carbamoyl phosphate biosynthetic process
GO:0071364 IEA cellular response to epidermal growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041895 cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase protein_coding Danio_rerio
ENSMUSG00000013629 Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase protein_coding Mus_musculus

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