C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000092010 PSME1 9606 + 14:24136158-24138967 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000206451 PSME1-001 24136158-24138967 protein_coding
  ENST00000382708 PSME1-005 24136200-24138964 protein_coding
  ENST00000470718 PSME1-004 24136228-24137761 processed_transcript
  ENST00000558112 PSME1-012 24137520-24138959 nonsense_mediated_decay
  ENST00000559123 PSME1-006 24136163-24138959 protein_coding
  ENST00000559741 PSME1-011 24137398-24138959 retained_intron
  ENST00000560420 PSME1-008 24137520-24138904 retained_intron
  ENST00000561059 PSME1-007 24136197-24138299 retained_intron
  ENST00000561142 PSME1-010 24136197-24138787 retained_intron
  ENST00000561435 PSME1-009 24136227-24138967 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000206451ENST00000470718ENST00000558112ENST00000559123ENST00000561142
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000206451 33.642±0.00 70.487±0.00 4.656±0.00 14.061±8.26 22.731±9.36 38.695±27.67 29.375±26.25 71.155±45.04 34.829±25.67 92.993±78.37 35.568±28.62 76.136±52.90 119.293±42.01 32.269±22.98
ENST00000470718 N/A N/A 8.303±0.00 N/A 9.539±0.00 N/A 4.314±0.00 N/A 5.606±0.00 N/A N/A 7.399±0.00 N/A N/A
ENST00000558112 42.163±0.00 91.095±0.00 N/A 32.399±0.00 39.092±0.00 54.328±0.00 N/A 80.722±0.00 24.523±0.00 N/A N/A 76.740±0.00 N/A 50.814±0.00
ENST00000559123 N/A N/A N/A N/A N/A 3.728±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000561142 23.673±0.00 48.015±0.00 2.036±0.00 N/A 19.892±0.00 N/A N/A N/A N/A N/A N/A 25.118±0.00 53.242±0.00 6.741±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00037E CIL_00037E_0001 CGP 14:24131275-24138967
CIL_00031C CIL_00031C_0001 CGP 14:24136158-24141588

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 TAS proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005515 IEA protein binding
GO:0005654 TAS nucleoplasm
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008537 IEA proteasome activator complex
GO:0010467 TAS gene expression
GO:0010950 IEA positive regulation of endopeptidase activity
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0019884 IEA antigen processing and presentation of exogenous antigen
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0061133 IEA endopeptidase activator activity
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002165 psme1 proteasome activator subunit 1 protein_coding Danio_rerio
ENSMUSG00000022216 Psme1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) protein_coding Mus_musculus

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