C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000099341 PSMD8 9606 + 19:38374536-38383824 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000215071 PSMD8-001 38374536-38383824 protein_coding
  ENST00000585598 PSMD8-005 38374758-38382847 protein_coding
  ENST00000590331 PSMD8-009 38380899-38383297 nonsense_mediated_decay
  ENST00000591216 PSMD8-006 38374770-38379363 retained_intron
  ENST00000591250 PSMD8-008 38375057-38379405 protein_coding
  ENST00000592001 PSMD8-007 38374788-38381235 retained_intron
  ENST00000592035 PSMD8-002 38375009-38382753 protein_coding
  ENST00000592561 PSMD8-004 38374772-38382254 protein_coding
  ENST00000602911 PSMD8-010 38374759-38383824 protein_coding
  ENST00000620216 PSMD8-201 38374550-38383823 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000592561ENST00000602911ENST00000620216
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000592561 51.845±0.00 20.642±0.00 N/A 14.451±0.00 30.258±24.32 30.856±0.00 61.658±0.00 20.455±14.67 25.694±20.74 17.976±14.79 105.379±0.00 28.210±3.55 20.559±0.00 43.805±1.46
ENST00000602911 55.555±0.00 42.438±0.00 4.657±0.00 34.424±7.83 24.026±19.82 19.304±9.31 43.664±30.93 33.702±23.62 21.541±18.05 27.890±22.87 77.574±51.73 42.551±26.54 119.398±61.43 30.814±14.23
ENST00000620216 N/A N/A N/A N/A 2.419±0.00 N/A N/A N/A N/A 2.113±0.00 N/A N/A N/A 19.056±1.52

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0005838 IEA proteasome regulatory particle
GO:0006508 IEA proteolysis
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0022624 ISS proteasome accessory complex
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020454 psmd8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 protein_coding Danio_rerio
ENSMUSG00000030591 Psmd8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 protein_coding Mus_musculus

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