C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, ATPase, 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100519 PSMC6 9606 + 14:52707172-52728587 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000445930 PSMC6-001 52707172-52728587 protein_coding
  ENST00000458604 PSMC6-009 52707184-52718688 retained_intron
  ENST00000551328 PSMC6-014 52718507-52720978 retained_intron
  ENST00000553798 PSMC6-006 52707231-52708666 nonsense_mediated_decay
  ENST00000553899 PSMC6-002 52707202-52713902 nonsense_mediated_decay
  ENST00000554044 PSMC6-005 52707209-52718339 nonsense_mediated_decay
  ENST00000554952 PSMC6-008 52707202-52710335 processed_transcript
  ENST00000554956 PSMC6-004 52707201-52708833 retained_intron
  ENST00000555175 PSMC6-012 52718231-52727994 nonsense_mediated_decay
  ENST00000555339 PSMC6-016 52707219-52718339 protein_coding
  ENST00000555887 PSMC6-003 52707178-52709089 retained_intron
  ENST00000556813 PSMC6-017 52707222-52724036 protein_coding
  ENST00000557085 PSMC6-011 52710546-52714032 retained_intron
  ENST00000557240 PSMC6-015 52707192-52718302 nonsense_mediated_decay
  ENST00000557517 PSMC6-007 52707287-52709607 nonsense_mediated_decay
  ENST00000557557 PSMC6-010 52721500-52727990 processed_transcript
  ENST00000557632 PSMC6-013 52723745-52727817 retained_intron
  ENST00000606149 PSMC6-018 52707204-52727991 protein_coding
  ENST00000612399 PSMC6-201 52707178-52727995 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000445930ENST00000555339ENST00000556813ENST00000557240ENST00000557557ENST00000606149ENST00000612399
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000445930 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.719±0.00 N/A N/A
ENST00000555339 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.585±0.00 N/A N/A N/A
ENST00000556813 N/A N/A 2.526±0.00 N/A N/A N/A 5.867±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000557240 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 38.593±0.00 19.111±0.00 N/A
ENST00000557557 N/A 3.317±0.00 0.594±0.00 2.620±0.00 2.278±0.16 N/A N/A N/A N/A 1.302±0.00 N/A 1.277±0.00 N/A N/A
ENST00000606149 14.776±0.00 12.502±0.00 3.415±0.00 18.198±0.91 13.720±1.55 13.550±6.10 11.531±4.89 17.118±6.28 14.085±0.43 8.768±1.26 8.362±4.91 29.313±16.06 14.212±0.76 17.891±6.72
ENST00000612399 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.028±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005GM CIL_0005GM_0001 CGP 14:52639916-52728587
CIL_0005GN CIL_0005GN_0001 CGP 14:52707172-52774998

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006200 TAS ATP catabolic process
GO:0006281 IEA DNA repair
GO:0006310 IEA DNA recombination
GO:0006511 IC ubiquitin-dependent protein catabolic process
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0009378 IEA four-way junction helicase activity
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016234 IEA inclusion body
GO:0016787 IEA hydrolase activity
GO:0016887 TAS ATPase activity
GO:0022624 ISS proteasome accessory complex
GO:0030163 IEA protein catabolic process
GO:0030674 NAS protein binding, bridging
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031597 IEA cytosolic proteasome complex
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070062 IDA extracellular vesicular exosome
GO:0090261 IEA positive regulation of inclusion body assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037038 psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 protein_coding Danio_rerio
ENSMUSG00000021832 Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 protein_coding Mus_musculus

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