C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dicer 1, ribonuclease type III
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100697 DICER1 9606 - 14:95086228-95158010 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000343455 DICER1-001 95086228-95157422 protein_coding
  ENST00000393063 DICER1-201 95086229-95141718 protein_coding
  ENST00000526495 DICER1-004 95086228-95158010 protein_coding
  ENST00000527414 DICER1-006 95090321-95136810 protein_coding
  ENST00000527416 DICER1-010 95088665-95091322 processed_transcript
  ENST00000527554 DICER1-011 95090665-95091422 retained_intron
  ENST00000529206 DICER1-005 95129061-95157486 retained_intron
  ENST00000529720 DICER1-003 95132611-95157270 protein_coding
  ENST00000531162 DICER1-002 95132611-95157270 protein_coding
  ENST00000532458 DICER1-009 95113130-95124275 processed_transcript
  ENST00000532939 DICER1-008 95095346-95103430 protein_coding
  ENST00000541352 DICER1-016 95090492-95133467 protein_coding
  ENST00000554367 DICER1-015 95103708-95106236 retained_intron
  ENST00000556045 DICER1-014 95090468-95106081 protein_coding
  ENST00000556681 DICER1-013 95106080-95107773 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000343455ENST00000393063ENST00000526495ENST00000527414ENST00000556045
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000343455 2.845±0.00 N/A 2.328±0.00 2.246±0.78 1.783±0.21 1.116±0.56 1.772±1.09 2.673±0.00 4.484±0.00 2.202±1.20 1.031±0.00 3.569±0.68 2.557±1.66 2.328±0.00
ENST00000393063 1.130±0.00 1.759±0.00 2.627±0.00 1.604±0.04 1.948±0.00 N/A 0.675±0.05 N/A 1.632±0.00 2.868±0.00 0.918±0.41 N/A 0.818±0.00 1.817±0.00
ENST00000526495 N/A N/A N/A 1.604±0.00 N/A N/A N/A N/A N/A N/A N/A 1.636±0.00 N/A 1.674±0.00
ENST00000527414 N/A N/A 2.883±0.00 3.891±0.00 7.261±0.00 2.667±0.00 0.679±0.00 3.672±0.00 6.069±0.00 8.219±0.00 2.176±0.00 2.747±1.06 N/A 6.545±0.00
ENST00000556045 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.130±0.00 5.352±0.00 8.747±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00019X CIL_00019X_0002 CGP 14:94768216-95158010
CIL_00085I CIL_00085I_0001 VISTA 14:95070077-95673144
CIL_0003QP CIL_0003QP_0001 CGP 14:95086228-95319906

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IEA angiogenesis
GO:0001942 IEA hair follicle development
GO:0003676 IEA nucleic acid binding
GO:0003677 IEA DNA binding
GO:0003723 IEA RNA binding
GO:0003725 IDA double-stranded RNA binding
GO:0004386 IEA helicase activity
GO:0004525 IDA:IEA ribonuclease III activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005793 IEA endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 TAS cytosol
GO:0006396 IEA RNA processing
GO:0008283 IEA cell proliferation
GO:0009791 IEA post-embryonic development
GO:0010070 IEA zygote asymmetric cell division
GO:0010467 TAS gene expression
GO:0010468 IEA regulation of gene expression
GO:0010626 ISS negative regulation of Schwann cell proliferation
GO:0010628 IEA positive regulation of gene expression
GO:0010660 IEA regulation of muscle cell apoptotic process
GO:0014040 ISS positive regulation of Schwann cell differentiation
GO:0014835 IEA myoblast differentiation involved in skeletal muscle regeneration
GO:0016442 IDA RISC complex
GO:0016787 IEA hydrolase activity
GO:0016891 IEA endoribonuclease activity, producing 5'-phosphomonoesters
GO:0019827 IEA stem cell maintenance
GO:0021522 IEA spinal cord motor neuron differentiation
GO:0021675 ISS nerve development
GO:0021889 IEA olfactory bulb interneuron differentiation
GO:0021987 IEA cerebral cortex development
GO:0030324 IEA lung development
GO:0030326 IEA embryonic limb morphogenesis
GO:0030422 IDA production of siRNA involved in RNA interference
GO:0030423 IMP targeting of mRNA for destruction involved in RNA interference
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0030426 IEA growth cone
GO:0031054 IDA pre-miRNA processing
GO:0031069 IEA hair follicle morphogenesis
GO:0031641 IEA regulation of myelination
GO:0031643 ISS positive regulation of myelination
GO:0032290 ISS peripheral nervous system myelin formation
GO:0035068 IEA micro-ribonucleoprotein complex
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0035196 ISS production of miRNAs involved in gene silencing by miRNA
GO:0035198 IEA miRNA binding
GO:0035264 IEA multicellular organism growth
GO:0042487 IEA regulation of odontogenesis of dentin-containing tooth
GO:0045069 IEA regulation of viral genome replication
GO:0045595 IEA regulation of cell differentiation
GO:0045664 IEA regulation of neuron differentiation
GO:0046872 IEA metal ion binding
GO:0048255 IEA mRNA stabilization
GO:0048536 IEA spleen development
GO:0048565 IEA digestive tract development
GO:0048608 IEA reproductive structure development
GO:0048713 IEA regulation of oligodendrocyte differentiation
GO:0048730 IEA epidermis morphogenesis
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0048812 ISS neuron projection morphogenesis
GO:0048856 IEA anatomical structure development
GO:0050767 IEA regulation of neurogenesis
GO:0051216 IEA cartilage development
GO:0051225 IEA spindle assembly
GO:0051252 IEA regulation of RNA metabolic process
GO:0051607 IEA defense response to virus
GO:0051726 IEA regulation of cell cycle
GO:0055013 IEA cardiac muscle cell development
GO:0060119 IEA inner ear receptor cell development
GO:0060576 IEA intestinal epithelial cell development
GO:0061309 IEA cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061548 IEA ganglion development
GO:0070173 IEA regulation of enamel mineralization
GO:0071335 IEA hair follicle cell proliferation
GO:0090501 IDA RNA phosphodiester bond hydrolysis
GO:0090502 IEA RNA phosphodiester bond hydrolysis, endonucleolytic
GO:2000628 IEA regulation of miRNA metabolic process
GO:2000630 IEA positive regulation of miRNA metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001129 dicer1 Dicer1, Dcr-1 homolog (Drosophila) protein_coding Danio_rerio
ENSMUSG00000041415 Dicer1 dicer 1, ribonuclease type III protein_coding Mus_musculus

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