C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100911 PSME2 9606 - 14:24143362-24147570 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000216802 PSME2-001 24143365-24147221 protein_coding
  ENST00000471700 PSME2-003 24143366-24146579 processed_transcript
  ENST00000558273 PSME2-004 24143405-24147235 nonsense_mediated_decay
  ENST00000558931 PSME2-005 24143407-24147258 retained_intron
  ENST00000559005 PSME2-007 24143362-24143952 retained_intron
  ENST00000559042 PSME2-008 24143367-24144009 retained_intron
  ENST00000559056 PSME2-015 24144203-24146314 protein_coding
  ENST00000559359 PSME2-009 24144034-24144657 retained_intron
  ENST00000559453 PSME2-006 24143382-24146238 retained_intron
  ENST00000559493 PSME2-010 24144800-24146578 retained_intron
  ENST00000559613 PSME2-012 24145741-24146629 processed_transcript
  ENST00000560370 PSME2-014 24143594-24146591 nonsense_mediated_decay
  ENST00000560410 PSME2-013 24143365-24146605 protein_coding
  ENST00000560592 PSME2-017 24145134-24146621 retained_intron
  ENST00000560788 PSME2-016 24145170-24146596 retained_intron
  ENST00000561103 PSME2-011 24146810-24147570 processed_transcript
  ENST00000615264 PSME2-201 24143365-24146646 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000216802ENST00000471700ENST00000560370ENST00000560410ENST00000615264
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000216802 N/A N/A N/A 2.710±0.00 N/A N/A 2.391±0.00 N/A N/A N/A N/A 67.810±0.00 N/A N/A
ENST00000471700 N/A N/A N/A N/A N/A 17.819±0.00 N/A 24.773±0.00 N/A N/A 5.652±0.00 N/A N/A N/A
ENST00000560370 23.792±0.00 N/A N/A N/A N/A 37.848±0.00 26.355±0.00 63.802±0.00 40.554±0.00 91.366±0.00 N/A N/A 19.503±0.00 N/A
ENST00000560410 20.264±0.00 155.891±0.00 N/A N/A 28.245±0.00 31.578±0.00 N/A 75.942±0.00 30.725±0.00 N/A N/A 77.505±19.99 47.633±23.05 52.308±0.00
ENST00000615264 21.316±0.00 106.504±0.00 3.924±0.00 N/A 20.759±3.76 23.476±4.82 15.002±12.68 37.733±13.48 22.404±16.09 69.360±0.00 N/A 8.115±0.00 43.750±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001K8 CIL_0001K8_0002 CGP 14:24138959-24147570
CIL_00031B CIL_00031B_0001 CGP 14:24143362-24160661

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 TAS proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008537 IEA proteasome activator complex
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033144 psme2 proteasome activator subunit 2 protein_coding Danio_rerio
ENSMUSG00000078153 Psme2b protease (prosome, macropain) activator subunit 2B protein_coding Mus_musculus
ENSMUSG00000079197 Psme2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) protein_coding Mus_musculus

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