C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cystatin C
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101439 CST3 9606 - 20:23626706-23638473 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000376925 CST3-001 23633648-23638026 protein_coding
  ENST00000398409 CST3-003 23633657-23638473 protein_coding
  ENST00000398411 CST3-002 23626706-23637945 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000376925ENST00000398409ENST00000398411
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000376925 423.056±0.00 199.785±0.00 11.351±0.00 184.633±34.47 323.520±320.15 409.787±0.00 187.868±183.71 160.955±144.02 178.056±156.90 300.709±286.08 176.046±142.47 170.449±150.89 245.026±32.88 272.425±34.45
ENST00000398409 71.373±0.00 162.479±0.00 N/A 163.361±107.11 19.416±0.00 97.894±83.12 5.693±0.00 23.451±0.00 122.808±0.00 61.918±51.17 60.611±0.00 207.764±147.66 294.110±65.01 314.922±0.00
ENST00000398411 N/A N/A N/A N/A 0.517±0.00 0.289±0.00 N/A N/A 0.446±0.00 N/A N/A 0.328±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004MQ CIL_0004MQ_0002 CGP 20:23626706-23689040

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001540 IPI beta-amyloid binding
GO:0002020 IPI protease binding
GO:0004866 IDA endopeptidase inhibitor activity
GO:0004869 IDA:IEA cysteine-type endopeptidase inhibitor activity
GO:0005515 IPI protein binding
GO:0005576 IMP extracellular region
GO:0005615 IDA extracellular space
GO:0006952 IDA defense response
GO:0010466 IDA negative regulation of peptidase activity
GO:0010711 IEP negative regulation of collagen catabolic process
GO:0010716 IEP negative regulation of extracellular matrix disassembly
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0034103 IEP regulation of tissue remodeling
GO:0043206 IGI extracellular fibril organization
GO:0045861 IDA negative regulation of proteolysis
GO:0060311 IMP negative regulation of elastin catabolic process
GO:0060313 IEP negative regulation of blood vessel remodeling
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007795 cst3 cystatin C (amyloid angiopathy and cerebral hemorrhage) protein_coding Danio_rerio
ENSDARG00000069192 zgc:163030 zgc:163030 protein_coding Danio_rerio

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