C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sodium leak channel, non-selective
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000102452 NALCN 9606 - 13:101053776-101416492 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000251127 NALCN-001 101053776-101416355 protein_coding
  ENST00000376200 NALCN-201 101368545-101399154 protein_coding
  ENST00000467264 NALCN-004 101116440-101143221 processed_transcript
  ENST00000470333 NALCN-003 101180373-101416492 processed_transcript
  ENST00000497170 NALCN-002 101142743-101416462 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000251127ENST00000376200ENST00000470333
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000251127 0.048±0.00 0.269±0.00 7.886±0.11 0.145±0.05 0.140±0.12 0.410±0.20 0.157±0.01 0.114±0.06 0.311±0.00 0.005±0.00 0.236±0.09 0.677±0.02 0.439±0.00
ENST00000376200 0.184±0.00 0.373±0.00 N/A 0.304±0.00 0.655±0.00 N/A 0.267±0.01 0.068±0.00 0.274±0.00 0.059±0.00 N/A N/A N/A
ENST00000470333 N/A N/A N/A N/A N/A 0.283±0.00 0.119±0.00 N/A N/A 0.125±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000WK CIL_0000WK_0001 CGP 13:100603927-101416492
CIL_0004G3 CIL_0004G3_0002 CGP 13:101053776-101720856

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005216 IEA ion channel activity
GO:0005245 IBA voltage-gated calcium channel activity
GO:0005272 TAS sodium channel activity
GO:0005515 IPI protein binding
GO:0005886 IBA plasma membrane
GO:0006811 IEA ion transport
GO:0008219 IEA cell death
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0034220 TAS ion transmembrane transport
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IEA sodium ion transmembrane transport
GO:0055085 TAS:IEA transmembrane transport
GO:0070509 IBA calcium ion import
GO:0070588 IBA calcium ion transmembrane transport
GO:0086010 IBA membrane depolarization during action potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001835 nalcn sodium leak channel, non-selective protein_coding Danio_rerio
ENSMUSG00000000197 Nalcn sodium leak channel, non-selective protein_coding Mus_musculus

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