C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ubiquitin protein ligase E3 component n-recognin 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000104517 UBR5 9606 - 8:102253012-102412841 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000220959 UBR5-002 102253736-102412689 protein_coding
  ENST00000517465 UBR5-012 102253946-102261986 retained_intron
  ENST00000518145 UBR5-007 102345896-102347000 retained_intron
  ENST00000518205 UBR5-004 102254198-102272931 protein_coding
  ENST00000519365 UBR5-008 102298867-102305257 protein_coding
  ENST00000519528 UBR5-014 102287505-102293709 processed_transcript
  ENST00000520539 UBR5-001 102253012-102412841 protein_coding
  ENST00000520898 UBR5-009 102298860-102305182 protein_coding
  ENST00000521312 UBR5-011 102265208-102267435 retained_intron
  ENST00000521566 UBR5-013 102271194-102276820 protein_coding
  ENST00000521767 UBR5-010 102265203-102268718 retained_intron
  ENST00000521922 UBR5-003 102254198-102412759 protein_coding
  ENST00000522327 UBR5-006 102359652-102361209 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000220959ENST00000518205ENST00000520539ENST00000521922
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000220959 4.222±0.00 4.207±0.00 1.328±0.00 1.915±0.09 4.003±0.61 2.757±0.45 3.164±0.00 1.564±0.00 1.402±0.00 5.902±0.00 5.620±0.00 3.662±1.06 1.336±0.00 11.090±0.00
ENST00000518205 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 24.751±0.00 5.235±0.00 24.017±7.43
ENST00000520539 1.824±0.00 N/A 1.256±0.00 2.567±0.00 4.421±0.00 1.599±0.00 1.380±0.40 N/A 5.282±0.00 N/A N/A 4.281±1.37 N/A 6.129±0.00
ENST00000521922 1.892±0.00 N/A N/A 2.008±0.27 4.452±0.00 4.452±0.00 1.952±0.28 1.813±0.61 6.956±0.00 3.804±0.00 N/A 2.024±0.00 2.715±2.29 18.014±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00000S CIL_00000S_0001 CGP 8:102204502-102412841
CIL_00000U CIL_00000U_0001 CGP 8:102253012-102561017

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000209 IDA protein polyubiquitination
GO:0003723 IEA RNA binding
GO:0004842 IEA:TAS ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IBA cytoplasm
GO:0006281 IEA DNA repair
GO:0006511 TAS ubiquitin-dependent protein catabolic process
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0008270 IEA zinc ion binding
GO:0008283 TAS cell proliferation
GO:0016020 IDA membrane
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0033160 IMP positive regulation of protein import into nucleus, translocation
GO:0034450 IDA ubiquitin-ubiquitin ligase activity
GO:0035413 IMP positive regulation of catenin import into nucleus
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043130 IEA ubiquitin binding
GO:0050847 IDA progesterone receptor signaling pathway
GO:0090263 IMP positive regulation of canonical Wnt signaling pathway
GO:1901315 IMP negative regulation of histone H2A K63-linked ubiquitination
GO:2000780 IMP negative regulation of double-strand break repair

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018192 ubr5 ubiquitin protein ligase E3 component n-recognin 5 protein_coding Danio_rerio
ENSMUSG00000037487 Ubr5 ubiquitin protein ligase E3 component n-recognin 5 protein_coding Mus_musculus

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