C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: growth factor receptor-bound protein 10
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106070 GRB10 9606 - 7:50590063-50793462 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000335866 GRB10-201 50590063-50793462 protein_coding
  ENST00000357271 GRB10-005 50592580-50732353 protein_coding
  ENST00000398810 GRB10-202 50590063-50705301 protein_coding
  ENST00000398812 GRB10-203 50590063-50732353 protein_coding
  ENST00000401949 GRB10-003 50592580-50782567 protein_coding
  ENST00000402497 GRB10-002 50592610-50793436 protein_coding
  ENST00000402578 GRB10-006 50590068-50727118 protein_coding
  ENST00000403097 GRB10-001 50590068-50792969 protein_coding
  ENST00000406641 GRB10-004 50592348-50756064 protein_coding
  ENST00000407526 GRB10-007 50592580-50756059 protein_coding
  ENST00000428711 GRB10-015 50617881-50626930 protein_coding
  ENST00000439044 GRB10-014 50674436-50793432 protein_coding
  ENST00000461886 GRB10-020 50592879-50595840 retained_intron
  ENST00000465602 GRB10-010 50727793-50747664 processed_transcript
  ENST00000467386 GRB10-012 50779457-50781471 processed_transcript
  ENST00000470992 GRB10-017 50755892-50781500 retained_intron
  ENST00000473696 GRB10-008 50595470-50607068 retained_intron
  ENST00000478162 GRB10-019 50779621-50781426 processed_transcript
  ENST00000482397 GRB10-009 50604909-50606413 retained_intron
  ENST00000483157 GRB10-011 50757116-50781401 processed_transcript
  ENST00000483819 GRB10-016 50755887-50782910 processed_transcript
  ENST00000490051 GRB10-018 50779718-50781430 retained_intron
  ENST00000492265 GRB10-013 50761658-50779570 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000335866ENST00000357271ENST00000398810ENST00000398812ENST00000401949ENST00000402497ENST00000402578ENST00000403097ENST00000406641ENST00000407526
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000335866 4.286±0.00 1.500±0.00 N/A N/A N/A 2.821±0.00 2.463±1.56 4.045±0.00 1.016±0.00 0.852±0.05 2.630±0.00 3.247±0.00 N/A 2.468±0.00
ENST00000357271 N/A N/A 1.942±0.00 N/A N/A 1.544±0.00 N/A N/A N/A 3.519±0.00 N/A N/A N/A N/A
ENST00000398810 N/A 2.468±0.00 N/A 2.491±0.83 1.277±0.00 4.260±0.00 4.403±0.00 2.092±1.05 1.753±0.00 1.295±0.00 8.661±0.00 1.380±0.00 1.533±0.63 4.063±0.00
ENST00000398812 5.084±0.00 1.378±0.00 N/A 3.252±0.00 N/A 7.744±0.00 N/A 1.456±0.00 N/A N/A N/A 3.568±0.00 4.441±0.45 2.486±0.00
ENST00000401949 N/A N/A N/A N/A N/A N/A 1.057±0.00 2.229±0.00 N/A N/A N/A N/A N/A N/A
ENST00000402497 6.584±0.00 N/A N/A N/A N/A N/A N/A N/A 3.164±0.00 3.988±0.00 5.088±0.86 9.535±5.83 3.097±0.07 10.247±0.00
ENST00000402578 N/A N/A N/A 1.273±0.00 0.625±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 2.511±0.00
ENST00000403097 N/A N/A 0.817±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000406641 N/A N/A N/A N/A 1.115±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000407526 N/A N/A N/A N/A 4.311±0.00 N/A N/A N/A 3.771±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008P3 CIL_0008P3_0001 VISTA 7:49993452-50594868
CIL_0008XT CIL_0008XT_0001 VISTA 7:50018042-50619048
CIL_0007SD CIL_0007SD_0001 VISTA 7:50081734-50682493
CIL_00089U CIL_00089U_0001 VISTA 7:50196544-50798008
CIL_0008KL CIL_0008KL_0001 VISTA 7:50358274-50958701
CIL_0004WV CIL_0004WV_0002 CGP 7:50458436-50793462
CIL_00072I CIL_00072I_0002 CGP 7:50590063-51316818

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005070 IEA SH3/SH2 adaptor activity
GO:0005158 ISS insulin receptor binding
GO:0005515 IPI protein binding
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0007165 IEA signal transduction
GO:0008286 ISS insulin receptor signaling pathway
GO:0030178 IDA negative regulation of Wnt signaling pathway
GO:0030949 IDA positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032868 ISS response to insulin
GO:0042326 IEA negative regulation of phosphorylation
GO:0042327 ISS positive regulation of phosphorylation
GO:0045719 ISS negative regulation of glycogen biosynthetic process
GO:0046325 ISS negative regulation of glucose import
GO:0046627 ISS negative regulation of insulin receptor signaling pathway
GO:0048009 IEA insulin-like growth factor receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002013 grb10a growth factor receptor-bound protein 10a protein_coding Danio_rerio
ENSDARG00000035308 grb10b growth factor receptor-bound protein 10b protein_coding Danio_rerio
ENSMUSG00000020176 Grb10 growth factor receptor bound protein 10 protein_coding Mus_musculus

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