C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: GLI family zinc finger 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106571 GLI3 9606 - 7:41960950-42237870 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000395925 GLI3-001 41960950-42237013 protein_coding
  ENST00000428534 GLI3-003 42222800-42237870 retained_intron
  ENST00000437480 GLI3-004 42172491-42237059 protein_coding
  ENST00000448703 GLI3-005 42048630-42227721 protein_coding
  ENST00000464291 GLI3-006 41972440-41977922 retained_intron
  ENST00000479210 GLI3-002 41964082-42152453 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000395925ENST00000448703ENST00000479210
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000395925 2.729±0.00 1.039±0.00 0.364±0.00 0.497±0.21 1.615±0.00 1.009±0.89 0.350±0.28 0.361±0.27 0.390±0.00 0.543±0.44 0.416±0.00 1.460±0.02 3.047±0.56 0.892±0.46
ENST00000448703 N/A N/A N/A N/A N/A 1.391±0.00 0.192±0.00 0.599±0.00 N/A N/A N/A N/A N/A N/A
ENST00000479210 N/A N/A N/A N/A N/A N/A 0.078±0.00 0.028±0.00 N/A 0.813±0.00 0.276±0.00 N/A N/A 0.862±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007Z6 CIL_0007Z6_0001 VISTA 7:41404793-42006682
CIL_0008OL CIL_0008OL_0001 VISTA 7:41719979-42321204
CIL_0007V6 CIL_0007V6_0001 VISTA 7:41846003-42447909
CIL_0008NK CIL_0008NK_0001 VISTA 7:41852129-42454039
CIL_0009D0 CIL_0009D0_0001 VISTA 7:41913232-42514961

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001656 IEA metanephros development
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001701 IEA in utero embryonic development
GO:0001822 IEA kidney development
GO:0002052 IEA positive regulation of neuroblast proliferation
GO:0003682 IEA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005929 IDA cilium
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007224 TAS smoothened signaling pathway
GO:0007389 IEA pattern specification process
GO:0007411 IEA axon guidance
GO:0007417 IEA central nervous system development
GO:0007420 IEA brain development
GO:0007442 IEA hindgut morphogenesis
GO:0007507 IEA heart development
GO:0008013 IPI beta-catenin binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009952 IEA anterior/posterior pattern specification
GO:0009953 IEA dorsal/ventral pattern formation
GO:0009954 IEA proximal/distal pattern formation
GO:0010468 IEA regulation of gene expression
GO:0016485 IEA protein processing
GO:0016592 IDA mediator complex
GO:0016607 IEA nuclear speck
GO:0017053 IEA transcriptional repressor complex
GO:0021513 IEA spinal cord dorsal/ventral patterning
GO:0021522 IEA spinal cord motor neuron differentiation
GO:0021537 IEA telencephalon development
GO:0021543 IEA pallium development
GO:0021544 IEA subpallium development
GO:0021631 IEA optic nerve morphogenesis
GO:0021766 IEA hippocampus development
GO:0021775 IEA smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776 IEA smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021798 IEA forebrain dorsal/ventral pattern formation
GO:0021801 IEA cerebral cortex radial glia guided migration
GO:0021861 IEA forebrain radial glial cell differentiation
GO:0021915 IEA neural tube development
GO:0022018 IEA lateral ganglionic eminence cell proliferation
GO:0030318 IEA melanocyte differentiation
GO:0030324 IEA lung development
GO:0030326 IEA embryonic limb morphogenesis
GO:0030879 IEA mammary gland development
GO:0030900 IEA forebrain development
GO:0032332 IEA positive regulation of chondrocyte differentiation
GO:0033077 ISS T cell differentiation in thymus
GO:0035035 IPI histone acetyltransferase binding
GO:0035108 IMP limb morphogenesis
GO:0035295 IEA tube development
GO:0042060 IEA wound healing
GO:0042127 IEA regulation of cell proliferation
GO:0042307 IEA positive regulation of protein import into nucleus
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042733 TAS embryonic digit morphogenesis
GO:0042826 IDA histone deacetylase binding
GO:0042981 IEA regulation of apoptotic process
GO:0043010 IEA camera-type eye development
GO:0043066 IEA negative regulation of apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0043585 TAS nose morphogenesis
GO:0043586 IEA tongue development
GO:0043627 IEA response to estrogen
GO:0045060 ISS negative thymic T cell selection
GO:0045595 IEA regulation of cell differentiation
GO:0045596 IEA negative regulation of cell differentiation
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045879 ISS negative regulation of smoothened signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046638 ISS positive regulation of alpha-beta T cell differentiation
GO:0046639 ISS negative regulation of alpha-beta T cell differentiation
GO:0046872 IEA metal ion binding
GO:0048557 IEA embryonic digestive tract morphogenesis
GO:0048566 TAS embryonic digestive tract development
GO:0048589 IEA developmental growth
GO:0048593 IEA camera-type eye morphogenesis
GO:0048598 IEA embryonic morphogenesis
GO:0048646 IEA anatomical structure formation involved in morphogenesis
GO:0048663 IEA neuron fate commitment
GO:0048704 IEA embryonic skeletal system morphogenesis
GO:0048709 IEA oligodendrocyte differentiation
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0048839 IEA inner ear development
GO:0048856 IEA anatomical structure development
GO:0060021 IEA palate development
GO:0060173 IEA limb development
GO:0060364 IEA frontal suture morphogenesis
GO:0060366 IEA lambdoid suture morphogenesis
GO:0060367 IEA sagittal suture morphogenesis
GO:0060594 IEA mammary gland specification
GO:0060831 IEA smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060840 IEA artery development
GO:0060873 IEA anterior semicircular canal development
GO:0060875 IEA lateral semicircular canal development
GO:0061005 IEA cell differentiation involved in kidney development
GO:0070242 ISS thymocyte apoptotic process
GO:0072372 IEA primary cilium
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033680 gli1 GLI-Kruppel family member 1 protein_coding Danio_rerio
ENSMUSG00000021318 Gli3 GLI-Kruppel family member GLI3 protein_coding Mus_musculus

Loading