C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: endoglin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106991 ENG 9606 - 9:127815012-127854756 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344849 ENG-001 127815017-127854636 protein_coding
  ENST00000373203 ENG-002 127815012-127854756 protein_coding
  ENST00000462196 ENG-003 127825789-127829804 processed_transcript
  ENST00000480266 ENG-201 127815013-127847167 protein_coding
  ENST00000486329 ENG-005 127819238-127824405 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000344849ENST00000373203ENST00000480266
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000344849 N/A N/A N/A 4.105±0.00 14.565±0.00 0.709±0.00 N/A N/A N/A N/A N/A 19.668±0.00 N/A 7.242±0.00
ENST00000373203 85.996±0.00 245.048±0.00 4.370±0.00 5.819±5.07 38.840±35.26 70.123±0.00 46.819±44.11 45.870±39.87 19.468±18.43 101.793±94.33 27.531±0.00 85.183±89.83 164.639±77.98 157.400±138.18
ENST00000480266 N/A N/A 2.484±0.00 0.375±0.00 1.967±0.00 2.722±0.00 0.861±0.00 4.031±0.00 1.179±0.00 2.787±0.00 4.523±0.00 3.810±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YA CIL_0008YA_0001 VISTA 9:127227593-127829012

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001300 IEP chronological cell aging
GO:0001525 IEA angiogenesis
GO:0001569 ISS patterning of blood vessels
GO:0001570 IMP vasculogenesis
GO:0001666 IDA response to hypoxia
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001937 IMP negative regulation of endothelial cell proliferation
GO:0001947 ISS heart looping
GO:0003084 IMP positive regulation of systemic arterial blood pressure
GO:0003273 IEA cell migration involved in endocardial cushion formation
GO:0004888 NAS transmembrane signaling receptor activity
GO:0005024 IDA transforming growth factor beta-activated receptor activity
GO:0005072 IDA transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0005114 IPI type II transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005534 IDA galactose binding
GO:0005539 IDA glycosaminoglycan binding
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005925 IDA focal adhesion
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0007155 IEA cell adhesion
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007507 IEA heart development
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010628 IEA positive regulation of gene expression
GO:0010862 IDA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016477 IMP cell migration
GO:0017015 IDA regulation of transforming growth factor beta receptor signaling pathway
GO:0022009 IMP central nervous system vasculogenesis
GO:0022617 IMP extracellular matrix disassembly
GO:0030155 TAS regulation of cell adhesion
GO:0030336 IDA negative regulation of cell migration
GO:0030509 TAS BMP signaling pathway
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030513 IDA positive regulation of BMP signaling pathway
GO:0031953 IDA negative regulation of protein autophosphorylation
GO:0031960 IEA response to corticosteroid
GO:0032967 IEA positive regulation of collagen biosynthetic process
GO:0034713 IPI type I transforming growth factor beta receptor binding
GO:0035556 IDA intracellular signal transduction
GO:0036273 IEA response to statin
GO:0042060 IMP wound healing
GO:0042127 TAS regulation of cell proliferation
GO:0042325 TAS regulation of phosphorylation
GO:0042803 IPI protein homodimerization activity
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048185 TAS activin binding
GO:0048745 ISS smooth muscle tissue development
GO:0048844 ISS artery morphogenesis
GO:0048845 ISS venous blood vessel morphogenesis
GO:0048870 IMP cell motility
GO:0050431 IPI transforming growth factor beta binding
GO:0051001 IMP negative regulation of nitric-oxide synthase activity
GO:0060326 IMP cell chemotaxis
GO:0060348 IEA bone development
GO:0060394 IMP negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0070022 IC transforming growth factor beta receptor homodimeric complex
GO:0070278 IEA extracellular matrix constituent secretion
GO:0070483 IDA detection of hypoxia
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071559 IEA response to transforming growth factor beta
GO:0072563 IEA endothelial microparticle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000026814 Eng endoglin protein_coding Mus_musculus

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