C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dual specificity phosphatase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108861 DUSP3 9606 - 17:43766121-43778988 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000226004 DUSP3-001 43766121-43778988 protein_coding
  ENST00000590342 DUSP3-002 43768386-43778935 nonsense_mediated_decay
  ENST00000590753 DUSP3-004 43766131-43774768 protein_coding
  ENST00000590935 DUSP3-003 43766512-43774938 protein_coding
  ENST00000591618 DUSP3-005 43774882-43778337 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000226004ENST00000590342ENST00000590753ENST00000590935
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000226004 21.762±0.00 24.459±0.00 4.265±0.00 17.039±0.94 13.101±10.08 13.848±10.08 21.861±8.06 25.211±8.64 18.850±7.95 13.615±8.75 37.783±21.08 12.605±3.31 14.621±3.39 11.884±7.14
ENST00000590342 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.991±0.00 N/A N/A
ENST00000590753 N/A N/A N/A N/A 10.936±0.00 12.523±0.00 N/A 16.671±0.00 N/A N/A N/A 8.070±0.00 5.162±0.00 8.671±0.00
ENST00000590935 N/A N/A 7.885±0.00 N/A N/A 4.957±0.00 5.075±0.00 N/A 6.859±0.00 3.698±0.00 13.521±0.00 1.189±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000996 CIL_000996_0001 VISTA 17:43262867-43863532
CIL_00090X CIL_00090X_0001 VISTA 17:43291368-43892559
CIL_000997 CIL_000997_0001 VISTA 17:43327654-43928719
CIL_0001CB CIL_0001CB_0001 CGP 17:43753731-43778988
CIL_00059Q CIL_00059Q_0001 CGP 17:43766121-43787612

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000188 IMP inactivation of MAPK activity
GO:0001701 IEA in utero embryonic development
GO:0001772 IDA immunological synapse
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004721 IEA phosphoprotein phosphatase activity
GO:0004725 IDA:IEA protein tyrosine phosphatase activity
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 IDA cytosol
GO:0006470 IEA protein dephosphorylation
GO:0008138 IDA:IEA protein tyrosine/serine/threonine phosphatase activity
GO:0016311 IEA dephosphorylation
GO:0016791 IEA phosphatase activity
GO:0033549 IMP MAP kinase phosphatase activity
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035335 IDA peptidyl-tyrosine dephosphorylation
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043409 IMP negative regulation of MAPK cascade
GO:0045087 TAS innate immune response
GO:0045931 IMP positive regulation of mitotic cell cycle
GO:0046329 IDA negative regulation of JNK cascade
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050860 IDA negative regulation of T cell receptor signaling pathway
GO:0050868 IDA negative regulation of T cell activation
GO:0051403 TAS stress-activated MAPK cascade
GO:0070062 IDA extracellular vesicular exosome
GO:0070373 IDA negative regulation of ERK1 and ERK2 cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061255 dusp3a dual specificity phosphatase 3a protein_coding Danio_rerio
ENSMUSG00000003518 Dusp3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) protein_coding Mus_musculus

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