C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: vitamin D (1,25- dihydroxyvitamin D3) receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000111424 VDR 9606 - 12:47841537-47943048 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000229022 VDR-201 47841539-47905031 protein_coding
  ENST00000395324 VDR-001 47841537-47943048 protein_coding
  ENST00000546653 VDR-007 47855634-47905016 protein_coding
  ENST00000547065 VDR-003 47844470-47905022 nonsense_mediated_decay
  ENST00000548664 VDR-006 47857661-47905040 protein_coding
  ENST00000549336 VDR-004 47841537-47905022 protein_coding
  ENST00000550314 VDR-008 47857648-47882935 protein_coding
  ENST00000550325 VDR-002 47842628-47905003 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000229022ENST00000546653ENST00000547065ENST00000549336ENST00000550314ENST00000550325
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000229022 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.433±0.00 0.303±0.00 N/A
ENST00000546653 N/A N/A N/A 1.242±0.00 N/A N/A 0.066±0.00 N/A N/A 1.907±0.00 N/A N/A
ENST00000547065 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.140±0.00 N/A 0.731±0.00
ENST00000549336 1.377±0.00 0.875±0.00 0.068±0.00 2.093±0.00 2.184±0.03 N/A 1.401±1.39 N/A N/A 0.889±0.52 1.157±0.10 0.526±0.00
ENST00000550314 N/A N/A N/A N/A N/A N/A N/A 1.575±0.00 1.566±0.00 N/A N/A N/A
ENST00000550325 N/A 1.228±0.00 N/A 0.419±0.00 2.202±0.00 0.033±0.00 N/A 0.277±0.00 0.799±0.00 0.311±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003DI CIL_0003DI_0002 CGP 12:47782722-47943048
CIL_0005YK CIL_0005YK_0001 CGP 12:47841537-47968878

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000902 IMP cell morphogenesis
GO:0001501 IEA skeletal system development
GO:0003677 IDA DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA:IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006816 IEA calcium ion transport
GO:0006874 IEA cellular calcium ion homeostasis
GO:0007165 TAS signal transduction
GO:0007275 IEA multicellular organismal development
GO:0007595 IEA lactation
GO:0008270 IEA zinc ion binding
GO:0008285 IDA negative regulation of cell proliferation
GO:0008434 IEA:IDA calcitriol receptor activity
GO:0009887 IEA organ morphogenesis
GO:0010467 TAS gene expression
GO:0010628 IMP positive regulation of gene expression
GO:0010839 IMP negative regulation of keratinocyte proliferation
GO:0010980 IDA positive regulation of vitamin D 24-hydroxylase activity
GO:0030522 IEA intracellular receptor signaling pathway
GO:0038183 IDA bile acid signaling pathway
GO:0038186 IDA lithocholic acid receptor activity
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0045618 IMP positive regulation of keratinocyte differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046697 IEP decidualization
GO:0046965 IPI retinoid X receptor binding
GO:0050892 IEA intestinal absorption
GO:0060058 IEA positive regulation of apoptotic process involved in mammary gland involution
GO:0060558 ISS regulation of calcidiol 1-monooxygenase activity
GO:0060745 IEA mammary gland branching involved in pregnancy
GO:0070561 IEA:IDA vitamin D receptor signaling pathway
GO:0070644 IDA vitamin D response element binding
GO:1902098 IDA calcitriol binding
GO:1902121 IDA lithocholic acid binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043059 VDR (1 of 2) vitamin D (1,25- dihydroxyvitamin D3) receptor protein_coding Danio_rerio
ENSDARG00000070721 vdrb vitamin D receptor b protein_coding Danio_rerio
ENSMUSG00000022479 Vdr vitamin D receptor protein_coding Mus_musculus

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