C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ring finger protein 8, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000112130 RNF8 9606 + 6:37353972-37394738 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000229866 RNF8-004 37354015-37391168 nonsense_mediated_decay
  ENST00000373479 RNF8-001 37353972-37394738 protein_coding
  ENST00000469316 RNF8-008 37354073-37368538 nonsense_mediated_decay
  ENST00000469731 RNF8-003 37354091-37391231 protein_coding
  ENST00000479516 RNF8-005 37354072-37370247 processed_transcript
  ENST00000487950 RNF8-007 37354064-37369030 protein_coding
  ENST00000494320 RNF8-006 37353979-37368874 nonsense_mediated_decay
  ENST00000498460 RNF8-002 37368876-37391062 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000229866ENST00000373479ENST00000469731ENST00000479516ENST00000487950ENST00000498460
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000229866 2.201±0.00 1.769±0.00 N/A 3.487±2.12 1.498±1.14 2.441±1.94 1.674±1.16 2.534±2.36 1.033±0.21 1.337±0.92 0.684±0.12 5.319±3.90 4.647±3.49 16.318±7.83
ENST00000373479 N/A N/A N/A 0.314±0.00 N/A N/A 0.230±0.00 N/A N/A 0.210±0.00 0.098±0.00 0.685±0.00 N/A 0.658±0.00
ENST00000469731 0.908±0.00 2.816±0.00 0.523±0.00 2.540±0.22 0.965±0.46 2.331±0.99 1.559±1.21 1.387±1.16 1.767±0.00 2.771±1.52 1.329±0.00 3.092±0.06 2.210±0.25 5.684±0.26
ENST00000479516 N/A N/A 1.078±0.00 N/A 0.628±0.00 0.760±0.00 N/A N/A 0.579±0.00 N/A N/A 0.724±0.00 N/A N/A
ENST00000487950 N/A N/A N/A N/A N/A N/A N/A N/A 1.462±0.00 N/A N/A N/A N/A N/A
ENST00000498460 N/A 2.918±0.00 0.721±0.00 N/A 1.702±0.00 N/A N/A N/A N/A N/A 1.305±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089L CIL_00089L_0001 VISTA 6:36799205-37399713
CIL_0005CZ CIL_0005CZ_0001 CGP 6:37257772-37394738
CIL_0001Z5 CIL_0001Z5_0001 CGP 6:37353972-37482827

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 IDA ubiquitin ligase complex
GO:0000781 ISS chromosome, telomeric region
GO:0003682 IDA chromatin binding
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0006302 IDA double-strand break repair
GO:0006303 ISS double-strand break repair via nonhomologous end joining
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007067 IEA mitotic nuclear division
GO:0007286 ISS spermatid development
GO:0008270 IDA zinc ion binding
GO:0010212 IDA response to ionizing radiation
GO:0016567 IEA protein ubiquitination
GO:0016881 IEA acid-amino acid ligase activity
GO:0031625 IPI ubiquitin protein ligase binding
GO:0033522 IDA histone H2A ubiquitination
GO:0033523 ISS histone H2B ubiquitination
GO:0034244 IMP negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035861 IDA site of double-strand break
GO:0036297 TAS interstrand cross-link repair
GO:0042393 IDA histone binding
GO:0042803 IDA protein homodimerization activity
GO:0043486 ISS histone exchange
GO:0045190 ISS isotype switching
GO:0045739 IDA positive regulation of DNA repair
GO:0046872 IEA metal ion binding
GO:0051301 IEA cell division
GO:0051865 IDA protein autoubiquitination
GO:0070534 IDA protein K63-linked ubiquitination
GO:0070535 IMP histone H2A K63-linked ubiquitination
GO:0070936 IDA protein K48-linked ubiquitination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044949 rnf8 ring finger protein 8, E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSMUSG00000090083 Rnf8 ring finger protein 8 protein_coding Mus_musculus
ENSMUSG00000098374 Gm28043 predicted gene, 28043 protein_coding Mus_musculus

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