C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: secreted protein, acidic, cysteine-rich (osteonectin)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000113140 SPARC 9606 - 5:151661096-151687165 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000231061 SPARC-001 151661096-151687165 protein_coding
  ENST00000520687 SPARC-002 151662488-151667654 retained_intron
  ENST00000521327 SPARC-003 151672597-151686975 retained_intron
  ENST00000521569 SPARC-005 151666477-151686968 protein_coding
  ENST00000522348 SPARC-004 151673178-151686963 protein_coding
  ENST00000524277 SPARC-006 151667474-151671829 retained_intron
  ENST00000537849 SPARC-009 151666425-151667584 processed_transcript
  ENST00000538026 SPARC-008 151666373-151686963 protein_coding
  ENST00000539687 SPARC-007 151671570-151685230 protein_coding
  ENST00000620972 SPARC-201 151661100-151685660 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000231061ENST00000520687ENST00000521569ENST00000620972
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000231061 N/A N/A 4.687±0.00 13.008±0.00 27.815±0.00 9.551±0.00 9.446±0.00 7.130±0.00 25.349±0.00 14.045±0.00 6.057±0.00 47.682±19.37 147.848±1.09 N/A
ENST00000520687 397.457±0.00 208.181±0.00 11.724±0.00 129.476±0.00 840.924±781.53 173.208±161.60 119.367±0.00 259.317±0.00 53.910±0.00 289.576±263.30 29.152±12.48 413.626±302.70 1320.976±890.89 445.485±60.20
ENST00000521569 N/A N/A 19.296±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000620972 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 58.807±10.75 323.088±0.00 86.098±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00025X CIL_00025X_0001 CGP 5:151504093-151687165
CIL_0007IC CIL_0007IC_0002 CGP 5:151661096-151772532

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 IEA ossification
GO:0001937 IDA negative regulation of endothelial cell proliferation
GO:0002576 TAS platelet degranulation
GO:0005509 IDA:IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005518 IDA collagen binding
GO:0005576 NAS extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005604 IEA basement membrane
GO:0005615 IEA extracellular space
GO:0005622 IEA intracellular
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0007165 IEA signal transduction
GO:0007507 IEA heart development
GO:0007596 TAS blood coagulation
GO:0009629 IEA response to gravity
GO:0009986 IDA cell surface
GO:0010288 IEA response to lead ion
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0016363 IDA nuclear matrix
GO:0016525 IDA negative regulation of angiogenesis
GO:0022604 IDA regulation of cell morphogenesis
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030324 IEA lung development
GO:0031012 IEA extracellular matrix
GO:0031091 IDA platelet alpha granule
GO:0031092 IDA platelet alpha granule membrane
GO:0031093 TAS platelet alpha granule lumen
GO:0031988 IEA membrane-bounded vesicle
GO:0032496 IEA response to lipopolysaccharide
GO:0033591 IEA response to L-ascorbic acid
GO:0034097 IEA response to cytokine
GO:0042060 IEA wound healing
GO:0042127 IEA regulation of cell proliferation
GO:0043434 IEA response to peptide hormone
GO:0045471 IEA response to ethanol
GO:0046686 IEA response to cadmium ion
GO:0048839 IEA inner ear development
GO:0050840 IEA extracellular matrix binding
GO:0051384 IEA response to glucocorticoid
GO:0051591 IEA response to cAMP
GO:0051592 IEA response to calcium ion
GO:0060348 IEA bone development
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071682 TAS endocytic vesicle lumen

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019353 sparc secreted acidic cysteine rich glycoprotein protein_coding Danio_rerio
ENSMUSG00000018593 Sparc secreted acidic cysteine rich glycoprotein protein_coding Mus_musculus

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