C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: orthodenticle homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115507 OTX1 9606 + 2:63050057-63057836 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000282549 OTX1-001 63050802-63057836 protein_coding
  ENST00000366671 OTX1-002 63050057-63057836 protein_coding
  ENST00000405984 OTX1-005 63050831-63056583 nonsense_mediated_decay
  ENST00000476383 OTX1-006 63050851-63052207 retained_intron
  ENST00000477348 OTX1-004 63050830-63051804 retained_intron
  ENST00000484066 OTX1-003 63050741-63053546 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastKidneyLiverLungOvaryPlacentaTestisENST00000282549ENST00000366671ENST00000405984ENST00000484066
Transcript ID Adipose Adrenal Brain Breast Kidney Liver Lung Ovary Placenta Testis
ENST00000282549 N/A N/A 0.310±0.15 0.151±0.00 N/A N/A N/A 0.144±0.00 0.008±0.00 N/A
ENST00000366671 N/A N/A 0.190±0.00 N/A 0.065±0.00 0.021±0.00 0.382±0.00 0.425±0.43 0.045±0.01 0.171±0.00
ENST00000405984 0.059±0.00 N/A 0.103±0.00 0.169±0.00 N/A N/A N/A 0.273±0.00 0.018±0.00 N/A
ENST00000484066 N/A 0.020±0.00 N/A N/A N/A N/A N/A N/A N/A 0.122±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000976 CIL_000976_0001 VISTA 2:62666720-63267794
CIL_0000RR CIL_0000RR_0002 CGP 2:62673851-63057836
CIL_00084N CIL_00084N_0001 VISTA 2:62678793-63279521
CIL_00090Q CIL_00090Q_0001 VISTA 2:62740879-63342178
CIL_00095K CIL_00095K_0001 VISTA 2:62748560-63349968
CIL_0007MW CIL_0007MW_0001 UCNEbase 2:62787578-63424747
CIL_000100 CIL_000100_0002 CGP 2:63050057-63827843

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0007275 IEA multicellular organismal development
GO:0009952 IEA anterior/posterior pattern specification
GO:0022037 IEA metencephalon development
GO:0030900 IEA forebrain development
GO:0030901 IEA midbrain development
GO:0042472 IEA inner ear morphogenesis
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048852 IEA diencephalon morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030703 otx1a orthodenticle homolog 1a protein_coding Danio_rerio
ENSDARG00000094992 otx1b orthodenticle homolog 1b protein_coding Danio_rerio
ENSMUSG00000005917 Otx1 orthodenticle homolog 1 protein_coding Mus_musculus

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