C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: kynureninase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115919 KYNU 9606 + 2:142877498-143055832 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264170 KYNU-001 142877498-143055832 protein_coding
  ENST00000375773 KYNU-003 142877657-142990052 protein_coding
  ENST00000409512 KYNU-002 142877664-143042172 protein_coding
  ENST00000410015 KYNU-004 142877666-142947421 protein_coding
  ENST00000424385 KYNU-005 142877684-142954871 nonsense_mediated_decay
  ENST00000460143 KYNU-006 142918679-142958075 retained_intron
  ENST00000612147 KYNU-008 142918679-142967494 protein_coding
  ENST00000613664 KYNU-009 142927659-142971393 protein_coding
  ENST00000621320 KYNU-007 142885395-142964752 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264170ENST00000375773ENST00000409512ENST00000410015ENST00000613664ENST00000621320
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264170 0.239±0.00 0.402±0.00 0.209±0.00 0.118±0.11 0.187±0.01 0.079±0.05 0.097±0.06 0.684±0.44 0.434±0.00 0.297±0.17 0.047±0.00 0.050±0.03 0.081±0.03 0.282±0.02
ENST00000375773 N/A N/A 1.044±0.00 0.024±0.00 0.553±0.00 N/A 0.081±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000409512 2.735±0.00 1.891±0.00 0.528±0.00 0.058±0.00 1.645±0.00 0.330±0.00 N/A 3.569±0.51 11.795±0.00 5.213±0.24 N/A 0.749±0.29 2.198±0.74 4.858±0.83
ENST00000410015 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.455±0.00 N/A N/A
ENST00000613664 N/A N/A N/A 0.284±0.00 N/A N/A N/A N/A N/A N/A 1.032±0.00 N/A N/A N/A
ENST00000621320 N/A N/A N/A N/A N/A N/A 0.126±0.00 N/A N/A N/A N/A N/A 0.570±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003NW CIL_0003NW_0001 CGP 2:140231423-143055832
CIL_0008RY CIL_0008RY_0001 VISTA 2:142856840-143457904
CIL_0006M7 CIL_0006M7_0001 CGP 2:142877498-143768352

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005737 IEA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005829 IDA cytosol
GO:0006569 IMP:IEA tryptophan catabolic process
GO:0008152 IEA metabolic process
GO:0009435 IEA NAD biosynthetic process
GO:0019441 IEA tryptophan catabolic process to kynurenine
GO:0019442 IEA tryptophan catabolic process to acetyl-CoA
GO:0019805 IDA quinolinate biosynthetic process
GO:0030170 IEA pyridoxal phosphate binding
GO:0030429 IDA:IEA kynureninase activity
GO:0034341 IDA response to interferon-gamma
GO:0034354 IEA 'de novo' NAD biosynthetic process from tryptophan
GO:0034516 IMP response to vitamin B6
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042803 IDA protein homodimerization activity
GO:0043420 IDA anthranilate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0097053 IEA L-kynurenine catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000028345 KYNU (1 of 2) kynureninase protein_coding Danio_rerio
ENSDARG00000096343 KYNU (2 of 2) kynureninase protein_coding Danio_rerio
ENSMUSG00000026866 Kynu kynureninase (L-kynurenine hydrolase) protein_coding Mus_musculus

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