C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear factor, erythroid 2-like 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000116044 NFE2L2 9606 - 2:177227595-177392697 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000397062 NFE2L2-001 177230305-177265131 protein_coding
  ENST00000397063 NFE2L2-002 177230305-177263800 protein_coding
  ENST00000421929 NFE2L2-009 177231851-177263800 protein_coding
  ENST00000423513 NFE2L2-006 177232277-177263454 protein_coding
  ENST00000430047 NFE2L2-010 177231790-177264823 protein_coding
  ENST00000446151 NFE2L2-008 177230308-177263572 protein_coding
  ENST00000448782 NFE2L2-013 177231714-177263567 protein_coding
  ENST00000449627 NFE2L2-012 177230990-177263511 protein_coding
  ENST00000458603 NFE2L2-014 177227595-177232487 protein_coding
  ENST00000462023 NFE2L2-011 177233879-177264659 retained_intron
  ENST00000464747 NFE2L2-003 177230308-177392697 protein_coding
  ENST00000477534 NFE2L2-007 177233477-177263537 retained_intron
  ENST00000586532 NFE2L2-016 177231805-177311277 protein_coding
  ENST00000588123 NFE2L2-015 177232499-177287777 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000397062ENST00000397063ENST00000446151ENST00000449627
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000397062 15.151±0.00 11.877±0.00 4.626±0.00 10.934±0.00 N/A 4.474±0.00 13.006±0.00 18.022±11.26 10.055±5.42 17.280±12.95 3.825±1.78 23.486±17.53 15.465±6.34 21.092±4.40
ENST00000397063 11.019±0.00 N/A N/A 6.657±1.58 3.461±0.00 3.922±0.00 3.945±0.00 16.002±0.00 5.704±0.00 11.191±0.00 N/A 17.034±6.38 N/A 12.108±0.00
ENST00000446151 N/A N/A N/A N/A N/A N/A 4.044±0.00 N/A N/A N/A 0.952±0.00 N/A N/A N/A
ENST00000449627 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 23.151±0.00 29.337±0.00 26.768±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00017P CIL_00017P_0001 CGP 2:177212563-177392697
CIL_00017Q CIL_00017Q_0001 CGP 2:177227595-177543836

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000785 IEA chromatin
GO:0000976 TAS transcription regulatory region sequence-specific DNA binding
GO:0000980 IEA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001205 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001221 IEA transcription cofactor binding
GO:0003677 IDA:IEA DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0010499 IDA proteasomal ubiquitin-independent protein catabolic process
GO:0010628 IGI positive regulation of gene expression
GO:0016567 IDA protein ubiquitination
GO:0019904 IPI protein domain specific binding
GO:0030194 IEA positive regulation of blood coagulation
GO:0030968 IEA endoplasmic reticulum unfolded protein response
GO:0034599 IEA cellular response to oxidative stress
GO:0036003 IMP positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036091 IEA positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 TAS transcription regulatory region DNA binding
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0045995 IEA regulation of embryonic development
GO:0060548 IEA negative regulation of cell death
GO:0070301 IMP cellular response to hydrogen peroxide
GO:0071356 IMP cellular response to tumor necrosis factor
GO:0071499 IMP cellular response to laminar fluid shear stress
GO:1902176 IMP negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1903206 IGI negative regulation of hydrogen peroxide-induced cell death
GO:2000121 IEA regulation of removal of superoxide radicals
GO:2000352 IMP negative regulation of endothelial cell apoptotic process
GO:2000379 IEA positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042824 nfe2l2a nuclear factor (erythroid-derived 2)-like 2a protein_coding Danio_rerio
ENSMUSG00000015839 Nfe2l2 nuclear factor, erythroid derived 2, like 2 protein_coding Mus_musculus

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