C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: histone deacetylase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000116478 HDAC1 9606 + 1:32292086-32333635 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000373548 HDAC1-001 32292086-32333635 protein_coding
  ENST00000428704 HDAC1-010 32292140-32329140 protein_coding
  ENST00000463172 HDAC1-003 32292137-32327445 processed_transcript
  ENST00000471488 HDAC1-009 32331536-32333079 retained_intron
  ENST00000472928 HDAC1-005 32292161-32327677 processed_transcript
  ENST00000476391 HDAC1-002 32329480-32333635 retained_intron
  ENST00000481281 HDAC1-006 32292135-32327674 processed_transcript
  ENST00000482310 HDAC1-007 32327274-32331582 processed_transcript
  ENST00000484305 HDAC1-008 32330149-32330875 retained_intron
  ENST00000490081 HDAC1-004 32327189-32331781 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000373548ENST00000428704ENST00000472928ENST00000476391ENST00000490081
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000373548 16.863±0.00 41.268±0.00 3.140±0.00 3.574±1.66 11.696±4.25 25.085±9.06 6.447±5.71 20.239±17.89 7.697±3.20 11.976±6.88 2.466±0.00 48.877±12.68 31.376±9.31 24.934±16.17
ENST00000428704 8.211±0.00 N/A N/A 7.752±0.00 N/A N/A N/A N/A N/A 6.725±0.00 N/A N/A N/A N/A
ENST00000472928 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.840±0.00 108.590±0.00 29.013±0.00 24.546±0.00
ENST00000476391 N/A 6.073±0.00 N/A 1.499±0.00 N/A N/A 0.294±0.00 N/A N/A N/A N/A 5.840±0.00 N/A N/A
ENST00000490081 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.767±0.00 122.909±0.00 26.115±0.00 26.767±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008AA CIL_0008AA_0001 VISTA 1:31744429-32345312

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000118 TAS histone deacetylase complex
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000278 TAS mitotic cell cycle
GO:0000785 IDA chromatin
GO:0000790 IDA nuclear chromatin
GO:0000976 ISS transcription regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047 IDA core promoter binding
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0001106 IDA RNA polymerase II transcription corepressor activity
GO:0003700 TAS sequence-specific DNA binding transcription factor activity
GO:0004407 TAS:IEA histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005737 TAS cytoplasm
GO:0005829 IDA cytosol
GO:0006338 IC chromatin remodeling
GO:0006351 TAS transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006476 IDA protein deacetylation
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007219 TAS Notch signaling pathway
GO:0007596 TAS blood coagulation
GO:0008134 TAS transcription factor binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0009913 ISS epidermal cell differentiation
GO:0010467 TAS gene expression
GO:0010870 IMP positive regulation of receptor biosynthetic process
GO:0016032 IEA viral process
GO:0016568 TAS chromatin modification
GO:0016575 IMP:IEA histone deacetylation
GO:0016580 IDA Sin3 complex
GO:0016581 IDA NuRD complex
GO:0019213 ISS deacetylase activity
GO:0019899 IPI enzyme binding
GO:0031492 IDA nucleosomal DNA binding
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032922 ISS circadian regulation of gene expression
GO:0033558 IDA protein deacetylase activity
GO:0033613 IPI activating transcription factor binding
GO:0042475 ISS odontogenesis of dentin-containing tooth
GO:0042733 ISS embryonic digit morphogenesis
GO:0042826 IPI histone deacetylase binding
GO:0043044 IDA ATP-dependent chromatin remodeling
GO:0043066 ISS negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043922 IMP negative regulation by host of viral transcription
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045786 TAS negative regulation of cell cycle
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0060766 IDA negative regulation of androgen receptor signaling pathway
GO:0060789 ISS hair follicle placode formation
GO:0061029 ISS eyelid development in camera-type eye
GO:0061198 ISS fungiform papilla formation
GO:0070491 IPI repressing transcription factor binding
GO:0070932 IDA histone H3 deacetylation
GO:0070933 IDA histone H4 deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015427 hdac1 histone deacetylase 1 protein_coding Danio_rerio
ENSMUSG00000028800 Hdac1 histone deacetylase 1 protein_coding Mus_musculus
ENSMUSG00000061062 Gm10093 predicted pseudogene 10093 protein_coding Mus_musculus

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