C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lysine (K)-specific methyltransferase 2A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000118058 KMT2A 9606 + 11:118436490-118526832 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000389506 KMT2A-015 118436513-118523917 protein_coding
  ENST00000392873 KMT2A-017 118481831-118491895 protein_coding
  ENST00000420751 KMT2A-004 118481988-118484331 processed_transcript
  ENST00000525408 KMT2A-014 118519559-118522193 retained_intron
  ENST00000527839 KMT2A-013 118519835-118522409 retained_intron
  ENST00000527869 KMT2A-016 118436762-118474307 protein_coding
  ENST00000528278 KMT2A-005 118500702-118503564 retained_intron
  ENST00000529852 KMT2A-006 118436744-118450746 protein_coding
  ENST00000531904 KMT2A-002 118436510-118484314 protein_coding
  ENST00000532204 KMT2A-010 118436744-118449984 protein_coding
  ENST00000533790 KMT2A-007 118436762-118478202 protein_coding
  ENST00000534085 KMT2A-009 118506561-118507765 retained_intron
  ENST00000534358 KMT2A-001 118436490-118526832 protein_coding
  ENST00000534678 KMT2A-008 118509946-118512382 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000389506ENST00000534358
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000389506 N/A N/A N/A 4.558±0.00 1.198±0.00 1.138±0.00 1.575±0.00 4.762±0.00 2.213±0.37 1.523±0.20 2.983±0.00 N/A N/A
ENST00000534358 1.932±0.00 2.560±0.00 2.961±0.00 1.308±0.76 2.589±0.00 1.314±0.47 1.797±0.00 3.595±0.00 2.797±0.00 0.432±0.00 2.774±0.53 0.295±0.00 2.744±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081E CIL_00081E_0001 VISTA 11:118137591-118740525

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 IEA DNA binding
GO:0003680 NAS AT DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 NAS sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005737 IDA cytoplasm
GO:0006306 IEA DNA methylation
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006461 IDA protein complex assembly
GO:0006915 IEA apoptotic process
GO:0008270 IDA:IEA zinc ion binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009952 IEA anterior/posterior pattern specification
GO:0032411 IMP positive regulation of transporter activity
GO:0035097 IDA:IEA histone methyltransferase complex
GO:0035162 TAS embryonic hemopoiesis
GO:0042800 IMP:IEA histone methyltransferase activity (H3-K4 specific)
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0043984 IMP histone H4-K16 acetylation
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045322 IDA unmethylated CpG binding
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0051568 IMP:IEA histone H3-K4 methylation
GO:0051569 IEA regulation of histone H3-K4 methylation
GO:0070577 IDA lysine-acetylated histone binding
GO:0071339 IDA MLL1 complex
GO:0080182 IDA histone H3-K4 trimethylation
GO:2001040 IMP positive regulation of cellular response to drug

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004537 kmt2a lysine (K)-specific methyltransferase 2A protein_coding Danio_rerio
ENSMUSG00000002028 Kmt2a lysine (K)-specific methyltransferase 2A protein_coding Mus_musculus

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