C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: apolipoprotein A-I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000118137 APOA1 9606 - 11:116835751-116837950 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000236850 APOA1-001 116835751-116837950 protein_coding
  ENST00000359492 APOA1-004 116835751-116837609 protein_coding
  ENST00000375320 APOA1-002 116835751-116837586 protein_coding
  ENST00000375323 APOA1-003 116835751-116837614 protein_coding
  ENST00000375329 APOA1-005 116835751-116837610 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000236850ENST00000359492ENST00000375320ENST00000375323ENST00000375329
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000236850 N/A 0.255±0.00 N/A 0.136±0.00 0.542±0.00 N/A 1.726±0.00 445.670±0.00 N/A N/A N/A N/A 7.011±0.00 50.956±0.00
ENST00000359492 N/A N/A 0.464±0.00 0.363±0.00 4.501±0.00 N/A 7.644±2.43 2139.970±0.00 593.452±591.63 0.372±0.00 0.246±0.00 24.018±15.89 11.022±10.02 135.235±0.00
ENST00000375320 0.336±0.00 0.384±0.00 N/A N/A 0.311±0.00 0.377±0.00 32.140±0.00 N/A 3690.070±0.00 1.123±0.00 N/A 0.137±0.00 N/A 200.730±59.02
ENST00000375323 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.626±0.00 0.558±0.00 N/A
ENST00000375329 N/A N/A N/A 0.240±0.00 N/A N/A N/A 0.464±0.00 N/A N/A 0.135±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008EK CIL_0008EK_0001 VISTA 11:116351165-116951910
CIL_0007RC CIL_0007RC_0001 VISTA 11:116660805-117262910

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001523 TAS retinoid metabolic process
GO:0001540 IDA beta-amyloid binding
GO:0001932 IEA regulation of protein phosphorylation
GO:0001935 IEA endothelial cell proliferation
GO:0002576 TAS platelet degranulation
GO:0002740 IDA negative regulation of cytokine secretion involved in immune response
GO:0005319 IEA lipid transporter activity
GO:0005515 IPI protein binding
GO:0005543 IDA phospholipid binding
GO:0005548 IEA phospholipid transporter activity
GO:0005576 TAS:IEA extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0005769 TAS early endosome
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006644 IEA phospholipid metabolic process
GO:0006656 IDA phosphatidylcholine biosynthetic process
GO:0006695 IEA cholesterol biosynthetic process
GO:0006869 IEA lipid transport
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007229 IDA integrin-mediated signaling pathway
GO:0007584 IEA response to nutrient
GO:0007596 TAS blood coagulation
GO:0007603 TAS phototransduction, visible light
GO:0008035 IEA high-density lipoprotein particle binding
GO:0008203 IMP cholesterol metabolic process
GO:0008211 IEA glucocorticoid metabolic process
GO:0008289 IEA lipid binding
GO:0009986 IEA cell surface
GO:0010804 IDA negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010873 IDA positive regulation of cholesterol esterification
GO:0010903 IDA negative regulation of very-low-density lipoprotein particle remodeling
GO:0014012 IEA peripheral nervous system axon regeneration
GO:0015485 IDA cholesterol binding
GO:0015914 IEA phospholipid transport
GO:0017127 IMP cholesterol transporter activity
GO:0018158 IDA protein oxidation
GO:0018206 IDA peptidyl-methionine modification
GO:0019899 IPI enzyme binding
GO:0019915 IEA lipid storage
GO:0030139 IDA endocytic vesicle
GO:0030168 TAS platelet activation
GO:0030300 IEA regulation of intestinal cholesterol absorption
GO:0030301 IDA cholesterol transport
GO:0030325 IEA adrenal gland development
GO:0031100 IEA organ regeneration
GO:0031410 IDA cytoplasmic vesicle
GO:0031982 IDA vesicle
GO:0032489 IDA regulation of Cdc42 protein signal transduction
GO:0033344 IDA cholesterol efflux
GO:0033700 IDA phospholipid efflux
GO:0034115 IDA negative regulation of heterotypic cell-cell adhesion
GO:0034190 IPI apolipoprotein receptor binding
GO:0034191 IPI apolipoprotein A-I receptor binding
GO:0034361 IDA very-low-density lipoprotein particle
GO:0034364 IDA high-density lipoprotein particle
GO:0034365 IEA discoidal high-density lipoprotein particle
GO:0034366 IDA spherical high-density lipoprotein particle
GO:0034375 IC high-density lipoprotein particle remodeling
GO:0034380 IDA high-density lipoprotein particle assembly
GO:0034384 IC high-density lipoprotein particle clearance
GO:0034774 TAS secretory granule lumen
GO:0035025 IDA positive regulation of Rho protein signal transduction
GO:0042157 TAS:IEA lipoprotein metabolic process
GO:0042158 IEA lipoprotein biosynthetic process
GO:0042493 IEA response to drug
GO:0042632 IMP cholesterol homeostasis
GO:0042802 IPI identical protein binding
GO:0043534 IEA blood vessel endothelial cell migration
GO:0043627 IEA response to estrogen
GO:0043691 IMP reverse cholesterol transport
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045499 IDA chemorepellent activity
GO:0050713 IDA negative regulation of interleukin-1 beta secretion
GO:0050728 IDA negative regulation of inflammatory response
GO:0050821 IDA protein stabilization
GO:0050919 IDA negative chemotaxis
GO:0051345 IDA positive regulation of hydrolase activity
GO:0051346 IEA negative regulation of hydrolase activity
GO:0051347 IEA positive regulation of transferase activity
GO:0051496 IDA positive regulation of stress fiber assembly
GO:0055085 TAS transmembrane transport
GO:0055091 IDA phospholipid homeostasis
GO:0055102 IEA lipase inhibitor activity
GO:0060192 IEA negative regulation of lipase activity
GO:0060228 IDA phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0060354 IDA negative regulation of cell adhesion molecule production
GO:0060761 IDA negative regulation of response to cytokine stimulus
GO:0070062 IDA extracellular vesicular exosome
GO:0070328 IDA triglyceride homeostasis
GO:0070508 IMP cholesterol import
GO:0070653 IPI high-density lipoprotein particle receptor binding
GO:0071682 TAS endocytic vesicle lumen
GO:0071813 IEA lipoprotein particle binding
GO:0072562 IDA blood microparticle
GO:1900026 IDA positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012076 apoa1a apolipoprotein A-Ia protein_coding Danio_rerio
ENSDARG00000086583 apoa1b apolipoprotein A-Ib protein_coding Danio_rerio
ENSMUSG00000032083 Apoa1 apolipoprotein A-I protein_coding Mus_musculus

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