C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mutL homolog 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000119684 MLH3 9606 - 14:75013764-75051532 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355774 MLH3-201 75013764-75051532 protein_coding
  ENST00000380968 MLH3-001 75013769-75051532 protein_coding
  ENST00000553263 MLH3-006 75049169-75051504 protein_coding
  ENST00000553713 MLH3-004 75016397-75046825 protein_coding
  ENST00000554697 MLH3-010 75015487-75023018 nonsense_mediated_decay
  ENST00000555144 MLH3-005 75022815-75046641 nonsense_mediated_decay
  ENST00000555415 MLH3-009 75016786-75019112 retained_intron
  ENST00000555499 MLH3-008 75030558-75046388 processed_transcript
  ENST00000555671 MLH3-011 75039911-75047201 processed_transcript
  ENST00000556257 MLH3-002 75016787-75051457 protein_coding
  ENST00000556453 MLH3-012 75022814-75046444 nonsense_mediated_decay
  ENST00000556740 MLH3-003 75016989-75049691 protein_coding
  ENST00000557648 MLH3-007 75049337-75051467 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000355774ENST00000380968ENST00000553713ENST00000554697ENST00000555144ENST00000555415ENST00000555671ENST00000556257ENST00000556740
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000355774 N/A N/A N/A 0.413±0.00 N/A N/A 0.209±0.00 N/A 0.182±0.00 0.834±0.00 N/A N/A 0.148±0.00 N/A
ENST00000380968 N/A N/A N/A N/A 0.551±0.00 N/A 0.258±0.00 N/A 0.624±0.00 N/A N/A 0.371±0.09 0.248±0.00 0.504±0.14
ENST00000553713 N/A N/A N/A N/A N/A N/A N/A N/A 0.529±0.00 N/A 0.812±0.39 2.047±0.19 0.618±0.00 1.278±0.00
ENST00000554697 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.869±0.00 N/A N/A N/A N/A
ENST00000555144 1.685±0.00 2.720±0.00 N/A 2.637±0.00 2.686±0.00 4.418±0.00 N/A 3.996±0.00 1.123±0.00 2.256±0.00 N/A N/A N/A 3.481±0.00
ENST00000555415 N/A N/A N/A N/A N/A N/A N/A N/A 1.412±0.00 N/A 1.862±0.00 4.459±0.00 2.333±0.00 4.132±0.00
ENST00000555671 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.606±0.00 N/A N/A N/A
ENST00000556257 0.552±0.00 0.579±0.00 N/A 1.150±0.00 0.583±0.00 1.249±0.00 0.399±0.00 1.190±0.00 N/A N/A 0.973±0.00 N/A N/A N/A
ENST00000556740 0.259±0.00 N/A 1.650±0.00 2.575±0.00 0.589±0.00 1.221±0.20 0.826±0.62 0.716±0.00 1.212±0.85 1.163±0.00 0.396±0.00 1.343±0.65 1.060±0.53 2.339±0.59

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00084S CIL_00084S_0001 VISTA 14:74936670-75538350
CIL_00085H CIL_00085H_0001 VISTA 14:74957721-75560295
CIL_0007PT CIL_0007PT_0001 VISTA 14:74957738-75560035
CIL_0005OJ CIL_0005OJ_0001 CGP 14:75002911-75051532
CIL_0003FY CIL_0003FY_0001 CGP 14:75013764-75069483

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000793 IEA condensed chromosome
GO:0000795 IBA synaptonemal complex
GO:0001673 IEA male germ cell nucleus
GO:0003682 IEA chromatin binding
GO:0003696 TAS satellite DNA binding
GO:0003697 IBA single-stranded DNA binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 TAS nucleus
GO:0005712 IBA chiasma
GO:0006200 IBA ATP catabolic process
GO:0006298 NAS:IEA mismatch repair
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007130 IEA synaptonemal complex assembly
GO:0007131 IEA:NAS reciprocal meiotic recombination
GO:0007140 IEA male meiosis
GO:0007144 IEA female meiosis I
GO:0008104 IEA protein localization
GO:0016887 IBA ATPase activity
GO:0019237 IEA centromeric DNA binding
GO:0030983 IEA mismatched DNA binding
GO:0032300 IBA mismatch repair complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056334 mlh3 mutL homolog 3 (E. coli) protein_coding Danio_rerio
ENSMUSG00000021245 Mlh3 mutL homolog 3 (E coli) protein_coding Mus_musculus

Loading