C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000119718 EIF2B2 9606 + 14:75002911-75012366 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000266126 EIF2B2-001 75002911-75012366 protein_coding
  ENST00000553401 EIF2B2-005 75003018-75007788 nonsense_mediated_decay
  ENST00000553539 EIF2B2-003 75002972-75005102 retained_intron
  ENST00000554748 EIF2B2-006 75005905-75007416 protein_coding
  ENST00000555522 EIF2B2-002 75002933-75005017 retained_intron
  ENST00000556028 EIF2B2-004 75002974-75007735 nonsense_mediated_decay
  ENST00000556668 EIF2B2-007 75006304-75009563 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000266126ENST00000553401ENST00000555522ENST00000556028ENST00000556668
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000266126 0.632±0.00 0.704±0.00 N/A 0.751±0.20 0.618±0.00 N/A N/A 0.528±0.15 0.581±0.00 0.300±0.00 0.344±0.00 0.502±0.00 N/A N/A
ENST00000553401 N/A N/A N/A N/A N/A N/A N/A 4.885±0.00 N/A N/A N/A 3.692±0.00 3.923±0.00 7.128±0.00
ENST00000555522 N/A N/A N/A 2.693±0.00 N/A N/A N/A 2.313±0.00 N/A N/A N/A N/A 3.201±0.00 N/A
ENST00000556028 9.856±0.00 6.662±0.00 N/A 7.366±0.00 7.215±0.00 N/A 7.725±0.00 9.380±0.00 4.741±0.00 11.257±0.00 N/A 2.313±0.39 2.963±0.00 7.101±0.00
ENST00000556668 7.787±0.00 7.300±0.00 4.912±0.00 7.385±1.22 5.156±2.14 3.280±0.00 3.966±2.79 5.677±3.38 5.586±0.27 4.807±3.98 6.238±1.83 6.211±4.65 10.611±5.54 12.296±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00084S CIL_00084S_0001 VISTA 14:74936670-75538350
CIL_0003G0 CIL_0003G0_0001 CGP 14:74941834-75012366
CIL_00085H CIL_00085H_0001 VISTA 14:74957721-75560295
CIL_0007PT CIL_0007PT_0001 VISTA 14:74957738-75560035
CIL_0005OJ CIL_0005OJ_0001 CGP 14:75002911-75051532

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001541 IMP ovarian follicle development
GO:0003743 IDA translation initiation factor activity
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005525 IDA GTP binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005851 IDA eukaryotic translation initiation factor 2B complex
GO:0006412 TAS translation
GO:0006413 IDA translational initiation
GO:0006446 IBA regulation of translational initiation
GO:0007417 IMP central nervous system development
GO:0009408 ISS response to heat
GO:0009749 ISS response to glucose
GO:0010467 TAS gene expression
GO:0014003 IMP oligodendrocyte development
GO:0042552 IMP myelination
GO:0043434 ISS response to peptide hormone
GO:0043547 IDA positive regulation of GTPase activity
GO:0044237 IEA cellular metabolic process
GO:0044267 TAS cellular protein metabolic process
GO:0051716 IDA cellular response to stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041397 eif2b2 eukaryotic translation initiation factor 2B, subunit 2 beta protein_coding Danio_rerio
ENSMUSG00000004788 Eif2b2 eukaryotic translation initiation factor 2B, subunit 2 beta protein_coding Mus_musculus

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