C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin-degrading enzyme
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000119912 IDE 9606 - 10:92451684-92574076 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265986 IDE-001 92451684-92574076 protein_coding
  ENST00000371581 IDE-201 92451684-92497761 protein_coding
  ENST00000436178 IDE-007 92510133-92541353 protein_coding
  ENST00000462988 IDE-004 92475972-92479735 processed_transcript
  ENST00000463640 IDE-005 92475945-92479587 processed_transcript
  ENST00000478361 IDE-002 92474472-92574067 nonsense_mediated_decay
  ENST00000492362 IDE-006 92480557-92497749 processed_transcript
  ENST00000496903 IDE-003 92454269-92497733 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265986ENST00000371581ENST00000496903
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265986 3.230±0.00 2.709±0.00 1.291±0.00 2.405±0.00 2.897±0.00 1.842±0.00 2.623±0.99 2.274±0.06 2.722±1.25 2.951±0.94 4.106±0.00 2.053±0.74 2.774±0.94 1.883±0.00
ENST00000371581 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.910±0.00 1.870±0.00 0.576±0.00 2.413±0.00
ENST00000496903 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.087±1.31

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00018P CIL_00018P_0001 CGP 10:92291163-92574076
CIL_00018U CIL_00018U_0001 CGP 10:92451684-92655395

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001540 IEA beta-amyloid binding
GO:0001948 IPI glycoprotein binding
GO:0003824 IEA catalytic activity
GO:0004222 IDA metalloendopeptidase activity
GO:0005102 IPI receptor binding
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005777 IDA peroxisome
GO:0005782 IEA peroxisomal matrix
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0006200 IEA ATP catabolic process
GO:0006508 IDA proteolysis
GO:0008270 IDA zinc ion binding
GO:0008286 NAS insulin receptor signaling pathway
GO:0008340 IDA determination of adult lifespan
GO:0009986 IDA cell surface
GO:0010815 IDA bradykinin catabolic process
GO:0010992 IDA ubiquitin homeostasis
GO:0016032 IEA viral process
GO:0016887 IEA ATPase activity
GO:0017046 IEA peptide hormone binding
GO:0031597 IEA cytosolic proteasome complex
GO:0031626 IEA beta-endorphin binding
GO:0032461 IDA positive regulation of protein oligomerization
GO:0042277 IPI peptide binding
GO:0042447 IEA hormone catabolic process
GO:0042803 IPI protein homodimerization activity
GO:0043130 IPI ubiquitin binding
GO:0043559 IDA insulin binding
GO:0044257 IEA cellular protein catabolic process
GO:0045861 IEA negative regulation of proteolysis
GO:0046872 IEA metal ion binding
GO:0050435 IDA beta-amyloid metabolic process
GO:0051260 IDA protein homooligomerization
GO:0051289 IEA protein homotetramerization
GO:0051291 IEA protein heterooligomerization
GO:0051603 IDA proteolysis involved in cellular protein catabolic process
GO:1901142 IDA insulin metabolic process
GO:1901143 IDA insulin catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075570 ide insulin-degrading enzyme protein_coding Danio_rerio
ENSMUSG00000056999 Ide insulin degrading enzyme protein_coding Mus_musculus

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