C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: helicase, lymphoid-specific
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000119969 HELLS 9606 + 10:94501434-94613905 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000239026 HELLS-201 94501434-94602098 protein_coding
  ENST00000348459 HELLS-001 94545817-94602099 protein_coding
  ENST00000371327 HELLS-002 94590699-94613905 protein_coding
  ENST00000371332 HELLS-202 94501434-94602098 protein_coding
  ENST00000394036 HELLS-203 94545922-94602098 protein_coding
  ENST00000394045 HELLS-204 94545922-94602098 protein_coding
  ENST00000419900 HELLS-003 94545790-94574106 protein_coding
  ENST00000462057 HELLS-004 94554124-94571280 processed_transcript
  ENST00000464030 HELLS-006 94590742-94592514 retained_intron
  ENST00000466552 HELLS-005 94569195-94574448 retained_intron
  ENST00000475263 HELLS-007 94596880-94601971 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000239026ENST00000348459ENST00000371327ENST00000371332ENST00000394045ENST00000419900ENST00000466552ENST00000475263
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000239026 0.083±0.00 N/A N/A 0.196±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000348459 0.078±0.00 0.678±0.00 0.431±0.00 N/A 0.629±0.34 N/A N/A 0.203±0.00 1.172±0.00 N/A 0.097±0.00 3.050±2.69 0.860±0.76 5.047±0.02
ENST00000371327 N/A 0.618±0.00 N/A 0.178±0.11 0.128±0.00 0.028±0.00 0.086±0.00 0.201±0.00 0.085±0.00 0.265±0.16 0.033±0.00 1.632±1.29 0.335±0.19 2.794±1.09
ENST00000371332 N/A N/A N/A N/A N/A N/A N/A 0.694±0.00 N/A N/A N/A N/A N/A N/A
ENST00000394045 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.398±0.00 N/A
ENST00000419900 N/A N/A 0.987±0.00 N/A N/A N/A 0.138±0.00 0.632±0.00 0.214±0.00 N/A N/A 3.287±0.00 1.601±0.00 N/A
ENST00000466552 N/A N/A N/A N/A N/A N/A N/A N/A 0.033±0.00 N/A N/A N/A N/A N/A
ENST00000475263 N/A N/A N/A N/A N/A 0.231±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00067M CIL_00067M_0001 CGP 10:94333226-94535930
CIL_0003RX CIL_0003RX_0001 CGP 10:94402504-94613905
CIL_00067G CIL_00067G_0001 CGP 10:94501434-94736190

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000775 ISS chromosome, centromeric region
GO:0001655 IEA urogenital system development
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0004386 IEA helicase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005721 ISS pericentric heterochromatin
GO:0006306 IEA DNA methylation
GO:0006342 IEA chromatin silencing
GO:0006346 ISS methylation-dependent chromatin silencing
GO:0006351 IEA transcription, DNA-templated
GO:0007067 IEA mitotic nuclear division
GO:0007275 ISS multicellular organismal development
GO:0010216 ISS maintenance of DNA methylation
GO:0016787 IEA hydrolase activity
GO:0031508 ISS pericentric heterochromatin assembly
GO:0043066 IEA negative regulation of apoptotic process
GO:0046651 ISS lymphocyte proliferation
GO:2001243 IEA negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000057738 hells helicase, lymphoid-specific protein_coding Danio_rerio
ENSMUSG00000025001 Hells helicase, lymphoid specific protein_coding Mus_musculus

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